grant
The dynamic role of the alveolar macrophage during pulmonary bacterial infection
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025Adoptive TransferAgonistAirway infectionsAllergyAlveolar MacrophagesApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Caspase 1AustraliaAwardB pseudomalleiB. pseudomalleiBacteriaBacterial InfectionsBacterial PneumoniaBiomedical EngineeringBlood monocyteBurkholderiaBurkholderia pseudomalleiCASP-1CASP1CASP1 geneCaspase-1Caspase-1 GeneCausalityCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCessation of lifeClinicalCollaborationsCommunicable DiseasesCommunitiesComplementComplement ProteinsDataDeathDevelopmentDevelopment PlansEmerging Communicable DiseasesEmerging Infectious DiseasesEtiologyFocal InfectionFoundationsGene ActivationGenesGoalsGram-Negative Bacterial InfectionsHost DefenseHumanICE ProteaseIFN-Gamma-Inducing Factor GeneIFN-gamma-Inducing FactorIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-18IL-18 GeneIL-1BCIL-1b Converting EnzymeIL-1gIL-1g GeneIL18IL18 ProteinIL18 geneIL1B-ConvertaseIL1BCIL1BCEIL1F4IL1F4 GeneImageImmuneImmune responseImmunesImmunologyImmunomodulationIn VitroInfectionInfectious DiseasesInfectious Diseases / LaboratoryInfectious Diseases ResearchInfectious DisorderInflammasomeInflammationInflammatoryInflammatory ResponseInjuryInnate Immune ResponseInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLungLung Respiratory SystemLung damageLung infectionsMGC12320MGC12320 GeneMarrow monocyteMeasuresMelioidosisMentorshipMiceMice MammalsMicroscopyModern ManMonitorMorbidityMorbidity - disease rateMurineMusNull MouseOrganismP pseudomalleiP. pseudomalleiPathogenicityPathologicPathway interactionsPhasePhosphorylationPhysiciansPlayPneumoniaPolymersProductionProgrammed Cell DeathProtein PhosphorylationPseudomonas pseudomalleiPublicationsPulmonary MacrophagesRecoveryResearchResearch TrainingRespiratory InfectionsRespiratory Tract InfectionsRiskRoleScientific PublicationScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSoutheast AsiaSoutheastern AsiaStimulator of Interferon GenesStudy modelsTestingTherapeuticUnited StatesUniversitiesVirulenceWashingtonWorkaerosolizedbacteria infectionbacteria pathogenbacteria pneumoniabacterial diseasebacterial pathogenbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbiological weaponbioweaponcGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcareer developmentcausationcomplementationcyclic GMP-AMP synthase/STINGcytokinedeath riskdevelopmentaldisease causationengineered immune systemhost responseimagingimmune engineeringimmune modulationimmune regulationimmune system responseimmunoengineeringimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedin vivoinfection localizedinflammatory environmentinflammatory milieuinjuriesinnate immune functioninnovateinnovationinnovativeinsightinterestliving systemlocal infectionlung injurylung pathogenlung repairlung tissue repairmonocytemortalitymortality riskmouse modelmultidisciplinarymurine modelnecrocytosispathogenpathogenic bacteriapathwaypolymerpolymericprogramspulmonarypulmonary damagepulmonary infectionspulmonary injurypulmonary pathogenpulmonary repairpulmonary tissue damagepulmonary tissue injuryrecruitresponsesocial role
Description preview
PROJECT SUMMARY
Gram-negative bacterial pulmonary infections are responsible for significant morbidity and mortality worldwide.
Burkholderia pseudomallei (Bps), a Gram-negative, facultatively intracellular bacterium and Tier 1 Select Agent,
causes melioidosis, a leading etiology of pulmonary infections globally. Pulmonary infection with Bps causes…
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