grant
The Diversity Outbred Diabetes Project
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Apr 2014Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY2026ATAC sequencingATAC-seqATACseqAcuteAdrenergic AntagonistsAdrenergic BlockadersAdrenergic BlockersAdrenergic Receptor AntagonistsAdrenergic Receptor BlockadersAdrenergic-Blocking AgentsAdrenolytic AgentsAdrenolytic DrugsAdrenolyticsAdult-Onset Diabetes MellitusAffectAnti-AdrenergicsAnti-adrenergic AgentsAntiadrenergic AgentsAntiadrenergicsAntigenic DeterminantsAssay for Transposase-Accessible Chromatin using sequencingB9 endocrine pancreasBasal Transcription FactorBasal transcription factor genesBasic Mechanisms of SUMOylationBeta CellBinding DeterminantsBiologic ModelsBiological ModelsBlood GlucoseBlood SugarCUT&RUNCell FunctionCell LineCell PhysiologyCell ProcessCellLineCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular biologyChromatinCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCoenzyme IICompensationDNA Binding DomainDNA-Binding Protein MotifsDataData SetDiabetes MellitusDysfunctionE1A Binding Protein p300EP300EP300 geneEndocrine Gland SecretionEndocrine PancreasEnvironmental FactorEnvironmental Risk FactorEnzyme GeneEnzymesEpidemicEpitopesEquilibriumExposure toExpression SignatureFingerprintFunctional disorderGWA studyGWASGene Action RegulationGene Expression ProfileGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic DiversityGenetic ScreeningGenetic TranscriptionGenetic VariationGenetic studyHormone secretionHormonesHumanHumulin RHyperglycemiaHyperinsulinemiaHyperinsulinismHypoglycemiaIn SituInbred Strains MiceIndividualInsulinInsulin CellInsulin ResistanceInsulin Secreting CellIslands of LangerhansIslet CellIslets of LangerhansKAT3BKO miceKetosis-Resistant Diabetes MellitusKnock-outKnock-out MiceKnockoutKnockout MiceLinkMaturity-Onset Diabetes MellitusMeasuresMediatingMetabolic stressMiceMice MammalsModel SystemModern ManMurineMusMutateNAD phosphateNAD(H) phosphateNADH phosphateNADPNADPHNIDDMNesidioblastsNicotinamide-Adenine Dinucleotide PhosphateNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNon-Polyadenylated RNANoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNuclearNull MouseNutrientOvernutritionOxidative Stress Induced Gene Expression Via Nrf2Oxidative Stress PathwayPancreatic IsletsPars endocrina pancreatisPathway interactionsPhenotypePhysiologicPhysiologicalPhysiopathologyPopulationPredispositionPropertyProtein FingerprintingProtein FingerprintsProteinsProteomicsPublishingQTLQuantitative Trait LociQuinone ReductasesRNARNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqRegular InsulinResearchRibonucleic AcidRiskRoleSUMOylationSedentary behaviorSedentary life-styleSingle Base PolymorphismSingle Nucleotide PolymorphismSiteSlow-Onset Diabetes MellitusSocietiesStable Diabetes MellitusStrains Cell LinesSubcellular ProcessSumoylation PathwaySusceptibilityT2 DMT2DT2DMTherapeuticTimeTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTriphosphopyridine NucleotideType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVariantVariationWorkadult onset diabetesallelic variantalpha-adrenergic receptorassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingattenuated insulin secretionbalancebalance functionblood glucose regulationblunted insulin secretioncell biologycell stresscultured cell linedecreased insulin releasedecreased insulin secretiondefective insulin secretiondetection of nutrientdiabetesdiabetes managementdiabetes mellitus managementdiabetes riskdiabeticdiabetic managementdiminished insulin releasediminished insulin secretiondrug-like chemicaldrug-like compounddrug-like moleculeendocrine cellenvironmental riskexhaustionforward geneticsgene expression patterngene expression signaturegenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variantglucose controlglucose homeostasisglucose regulationglucose tolerancehESChistone acetyltransferase p300hormonal secretionhuman ES cellhuman ESChuman embryonic stem cellhuman modelhuman subjecthyperglycemichypoglycemichypoglycemic episodesimpaired insulin releaseimpaired insulin secretionimprovedinadequate insulin releaseinadequate insulin secretioninnovateinnovationinnovativeinsightinsulin regulationinsulin resistantinsulin secretioninsulin toleranceisletketosis resistant diabetesknock-downknockdownlowered insulin secretionmaturity onset diabetesmodel of humanmouse geneticsmultiomicsmultiple omicsnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynon-diabeticnondiabeticnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetnutrient sensingoverexpressoverexpressionp300panomicspathophysiologypathwayperception of nutrientspreventpreventingreduced insulin releaseresponserestorationsedentary lifestylesingle nucleotide variantsmall moleculesocial rolesuppressed insulin releasesuppressed insulin secretiontraittranscription factortranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtype 2 DMtype II DMtype two diabeteswhole genome association analysiswhole genome association studyα-adrenergic receptorβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY/ABSTRACT
Type 2 diabetes (T2D) is characterized by the inability of pancreatic islet β-cells to meet insulin demands, often
due to genetic and environmental factors that disrupt β-cell function. Most genetic variants associated with T2D
affect the differentiation, survival, and nutrient sensing of islet cells, as well as insulin…
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