grant
The development & pilot implementation of a Cas13a-based low-cost point-of-care assay for detecting Neisseria gonorrhoeae and molecular markers of antimicrobial resistance in resource-limited settings
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 19 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AIDSAccelerationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAddressAfricaAgreementAnti-microbial susceptibilityAntibiotic AgentsAntibiotic DrugsAntibioticsAntimicrobial ResistanceAreaAssayAutomobile DrivingBechuanalandBioassayBioinformaticsBiological AssayBlindnessBotswanaCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCannot achieve a pregnancyCas nuclease technologyCefiximeCephalosporin ResistanceCephalosporinsCiprofloxacinClinicClinicalClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodonCodon NucleotidesCollaborationsDNA GyraseDNA mutationDNA seqDNA sequencingDNAseqDataDetectionDevelopmentDiagnosisDiagnosticDiagnostic testsDifficulty conceivingDisease SurveillanceDrug Resistance in N. GonorrhoeaeDrug resistance in Neisseria GonorrhoeaeDrug resistant N. GonorrhoeaeDrug-resistant N. GonorrhoeaeDrug-resistant Neisseria GonorrhoeaeEnzyme GeneEnzymesEpidemiologyEvaluationFluorescenceFunctional MetagenomicsFutureGeneral HospitalsGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenotypeGoalsGonococcal InfectionGonococcusGonorrheaHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHealthHealth InequityHospitalsHuman T-Lymphotropic Virus Type III InfectionsIn VitroInequalities in HealthInequities in HealthInfectionInfertilityInfrastructureK23 AwardK23 MechanismK23 ProgramLaboratoriesLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMassachusettsMedicineMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMentorshipMetagenomicsMethodsMicrofluidicsMiscellaneous AntibioticMolecularMutationN gonorrheaN. gonorrheaNational Institutes of HealthNeisseria gonorrhoeaeNeisseria gonorrhoeae antibiotic resistanceNeonatalNucleic Acid Amplification TestsNucleic Acid TestingOrthologOrthologous GenePathogen detectionPatientsPelvic Inflammatory DiseasePerformancePhenotypePredispositionPreparationProviderPublic HealthPublicationsReporterResearchResearch InfrastructureResearch PriorityResearch SpecimenResistanceResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingRiskSamplingScientific PublicationScientistSexual HealthSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionSpecimenSusceptibilityTechniquesTechnologyTest ResultTestingTrainingUnited States National Institutes of HealthVenereal DiseasesVenereal DisordersVenereal InfectionsWomanWorkacceptability and feasibilityadverse consequenceadverse outcomeanti-microbial resistance emergenceanti-microbial resistantantibiotic resistant N. gonorrhoeaeantibiotic resistant Neisseria gonorrhoeaeantibiotic-resistant N. gonorrhoeaeantimicrobial resistance emergenceassay developmentcareercareer developmentcephalosporin resistantcostdesigndesigningdetection assaydevelopmentaldiagnostic assaydiagnostic technologiesdisparity in healthdrivingemerging anti-microbial resistanceemerging antimicrobial resistanceentire genomeepidemiologicepidemiologicalexperiencefertility cessationfertility lossfull genomegenome mutationgenome sequencinggenomic epidemiologygonococcal antibiotic resistancehealth disparityhealth inequalitiesimplementation scienceimprovedin vitro Assayinfertileinnovateinnovationinnovativeinsightinstructorinterestisothermal amplificationlab experiencelab traininglaboratory experiencelaboratory traininglateral flow assaylateral flow testmicrobial genomicsmolecular biomarkermolecular markernew approachesnew diagnosticsnext generation diagnosticsnovelnovel approachesnovel diagnosticsnovel strategiesnovel strategypelvic inflammation diseasepelvic inflammation disorderpelvic inflammatory disorderpelvic inflammatory syndromepoint of carepoint of care testingpoint-of-care detectionpredictive assaypredictive testpreparationspressureresistance mutationresistance to anti-microbialresistance to cephalosporinresistantresistant mutationresistant to antimicrobialresistant to cephalosporinscale upsexually acquired infectionvision lossvisual losswhole genomeµfluidic
Description preview
PROJECT SUMMARY
Low-resource settings have a high burden of Neisseria gonorrhoeae infection, but insufficient laboratory
infrastructure for diagnostic tests and antimicrobial susceptibility determination, leading to syndromic
management, which misses a high proportion of cases and results in the overuse of antibiotics. Together, those
factors…
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