grant
The Delta Ecology of NSCLC Treatment
Organization H. LEE MOFFITT CANCER CTR & RES INSTLocation TAMPA, UNITED STATESPosted 15 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025After CareAfter-TreatmentAftercareAnatomic SitesAnatomic structuresAnatomyAutomobile DrivingAutoregulationBiologic ModelsBiological ModelsBionomicsBody TissuesC-K-RASCalibrationCancer TreatmentCancersCell BodyCellsClinicalClinical DataCollaborationsCollectionComplexComputing MethodologiesDNA mutationDataData BanksDatabanksDevelopmentDiseaseDisease ProgressionDisorderEGF ReceptorEGFRERBB ProteinEcologic SystemsEcological ChangeEcological SystemsEcologyEcosystemEncapsulatedEngineeringEnvironmentEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEvolutionExtinctionFailureFibroblastsGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGoalsGrantGrowthHER1HomeostasisHost-Tumor InteractionHumanImmuneImmune mediated therapyImmune responseImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunologistImmunotherapyIn VitroIndividualInfiltrationInvadedK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS2KRAS2 geneKi-RASKnowledgeLungLung NeoplasmsLung Respiratory SystemLung TumorMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMathMath ModelsMathematicsMicroanatomyMicroscopic AnatomyModel SystemModelingModern ManMolecularMutateMutationNSCLCNSCLC - Non-Small Cell Lung CancerNeoplasmsNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaNormal CellNutrientO elementO2 elementOncogene K-RasOncologistOncologyOncology CancerOrganOutcomeOxygenPathologistPatientsPhilosophyPhysiological HomeostasisPopulationProcessProductionProliferatingPropertyPulmonary CancerPulmonary NeoplasmsPulmonary malignant NeoplasmRASK2RelapseResearch ResourcesResistanceResistance developmentResistant developmentResource SharingResourcesSamplingShapesTGF-alpha ReceptorTestingTherapeuticTherapy Clinical TrialsThoracic OncologyTimeTissue GrowthTissuesTransforming Growth Factor alpha ReceptorTreatment ProtocolsTreatment RegimenTreatment ScheduleTumor CellUrogastrone ReceptorWorkanti-cancer therapyc-erbB-1c-erbB-1 Proteincancer cellcancer progressioncancer therapycancer-directed therapycell transformationcell typeclinical decision-makingcomputational methodologycomputational methodscomputer based methodcomputer based predictioncomputer methodscomputing methodcytokinecytotoxicdata depositorydata repositorydata set repositorydataset repositorydeveloping resistancedevelopmentaldriver lesiondriver mutationdrivingerbB-1erbB-1 Proto-Oncogene ProteinerbBlfitnessgenome mutationhost neoplasm interactionhost responseimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponsein silicoin vivoinhibitor druginhibitor therapeuticinhibitor therapylung cancermalignancymath analysismath methodologymath methodsmathematic modelmathematical analysismathematical approachmathematical methodologymathematical methodsmathematical modelmathematical modelingmathematics analysismathematics approachmathematics methodologymathematics methodsmultidisciplinaryneoplasianeoplasm progressionneoplasm/cancerneoplasticneoplastic cellneoplastic growthneoplastic progressionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyoutcome predictionpost treatmentpredictive modelingpressureproto-oncogene protein c-erbB-1resistantresponseresponse to therapyresponse to treatmentsuccesstargeted agenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy responsetooltransformed cellstreatment responsetreatment responsivenesstreatment strategytumortumor behaviortumor growthtumor progressionv-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog
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Summary – Moffitt CSBC Proposal Overview
The Moffitt CSBC proposal is focused on the essential and highly dynamical interplay between cancer cell
evolution and the constantly changing ecology of the lung microenvironment. Tumors are not simply collections
of mutated cells that grow in isolation. Rather, they respond to and modify both the…
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