grant
The Darbepoetin Kindergarten Development Study
Organization RESEARCH TRIANGLE INSTITUTELocation RESEARCH TRIANGLE PARK, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20250-11 years old1-5 years old2 year old2 years of age4 year old4 years of age6-11 years oldAcademic achievementAcademic skillsActive Follow-upAdoptedAffectAfter CareAfter-TreatmentAftercareAgeAnimal ModelAnimal Models and Related StudiesBehaviorBehavior assessmentBirthBrainBrain Nervous SystemCare GiversCaregiversChildChild Behavior ChecklistChild Behavioral ChecklistChild YouthChildhoodChildhood Behavior ChecklistChildren (0-21)Children Behavior ChecklistClinical DataCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsDataDevelopmentDimensionsDisturbance in cognitionEncephalonEnrollmentErythropoiesisEvaluationExposure toFamilyFundingGoalsHistoryHumanImpaired cognitionInfantInfrastructureInvestigatorsMasksMediatingMediatorModern ManMotorMotor SkillsMovementMulti-center Neonatal Research NetworkMulticenter Neonatal Research NetworkNHLBINational Heart, Lung, and Blood InstituteNational Institutes of HealthNatureNeonatal Intensive Care UnitsNeonatal Research NetworkNeural DevelopmentNeuroprotectantsNeuroprotective AgentsNeuroprotective DrugsNewborn Intensive Care UnitsNursery SchoolsOutcomeOutcome AssessmentParentsParticipantParturitionPlacebosPremature InfantPreschool ChildRandomization trialRandomizedRecording of previous eventsRed Cell Mass resultRed Cell MassesReportingResearchResearch PersonnelResearchersRoleSchool-Age PopulationSchoolsSham TreatmentSiteSocio-economic statusSocioeconomic StatusTestingTimeToddlerUnited StatesUnited States National Institutes of HealthVLBWVery Low Birth Weight InfantVulnerable Populationsactive followupage 2 yearsage 4 yearsaged 2 yearsaged two yearsagesbehavior outcomebehavioral assessmentbehavioral outcomebiological sexbody movementclinical research siteclinical sitecognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingcohortdevelopmentalearly childhoodemotional functioningenrollerythroid developmentexecutive controlexecutive functionexperienceextreme prematurityextremely premature infantextremely pretermextremely preterm infantfollow upfollow-upfollowed upfollowupfour year oldfour years of agehigh riskhigh risk infanthistoriesimprovedimproved outcomeinfants born prematureinfants born prematurelyinsightinterestinterpersonal competenceinterpersonal competencykidskindergartenmiddle childhoodmodel of animalmotor abilitymotor impairmentmovement impairmentmovement limitationmultidisciplinaryneonatal ICUneonatal exposureneurodevelopmentneuroprotectionneuroprotectiveneurorestorationneurorestorativenovelparentparticipant enrollmentpatient enrollmentpediatricpeerphonologypost treatmentpre-clinicalpre-kpre-kindergartenpreclinicalpremature babypremature infant humanpreschoolpreschool child (1-5)preterm babypreterm infantpreterm infant humanrandomisationrandomizationrandomized trialrandomly assignedroutine therapyschool agesham therapysocial competencesocial competencysocial rolesocial skillssocio-economic positionsocioeconomic positionteachertwo year oldtwo years of agevery low birth weightvery prematurevery pretermvulnerable groupvulnerable individualvulnerable infantvulnerable peopleyoungster
Description preview
PROJECT SUMMARY/ABSTRACT
Improved survival of very preterm infants has not translated into improved neurodevelopment at school age.
One promising neuroprotective therapy is the use of erythropoiesis stimulating agents (ESAs) such as
darbepoetin. Preclinical and preliminary clinical data suggest that darbepoetin treatment will lead to improved…
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