grant
The coordination of cell size control and cell cycle regulation at developmental extremes
Organization DARTMOUTH COLLEGELocation HANOVER, UNITED STATESPosted 22 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AffectBiogenesisBiologic ModelsBiological ModelsBlastosphereCancersCell BodyCell CycleCell Cycle ControlCell Cycle ProgressionCell Cycle RegulationCell Division CycleCell NucleusCell SizeCell modelCellsCellular ExpansionCellular GrowthCellular biologyCellular modelCharacteristicsChromatinCouplingCytoplasmDNA damage check pointDNA damage check point responseDNA damage checkpointDNA damage checkpoint responseDevelopmentDrosophilaDrosophila genusEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentGeneralized GrowthGoalsGrowthHealthHistone H3HistonesHumanKinasesMalignant NeoplasmsMalignant TumorMeasuresModel SystemModern ManMolecularNuclearNucleusNursesOocytesOogenesisOrigin of LifeOvocytesPathway interactionsPhosphotransferase GenePhosphotransferasesPolyploidPolyploidyPreimplantation EmbryoProcessSystemTissue ArraysTissue ChipTissue GrowthTissue MicroarrayTranscription InitiationTransphosphorylasesWorkblastocystblastulacell biologycell growthcell typedevelopmentaleggfruit flyhuman diseaseinhibitorinsightmalignancyneoplasm/cancernurseontogenypathwaypre-implantation embryopreventpreventing
Description preview
PROJECT SUMMARY/ABSTRACT
A fundamental question in cell biology is how cells measure and maintain their characteristic sizes. We use two
systems in Drosophila development to study cell size control that provide a natural system for uncoupling
growth and division: embryogenesis and oogenesis. The early embryo is an extremely large cell that…
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