grant
The control of gene expression by eukaryotic ribonucleases
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Jan 2019Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AffectAreaBiogenesisBromodomainCancersChromatin Remodeling ComplexChromatin Remodeling FactorCytoplasmDNA mutationDegradation PathwayDegradative PathwayDiseaseDisorderExonucleaseGene ExpressionGene TranscriptionGenetic ChangeGenetic DiseasesGenetic TranscriptionGenetic defectGenetic mutationHybridsLaboratoriesLinkMalignant NeoplasmsMalignant TumorMessenger RNAMolecularMutationNon-Polyadenylated RNANuclearNuclear RNANuclear RNase III DroshaOrigin of LifePlayPontocerebellar hypoplasiaProcessProteinsProteomeQuality ControlRNARNA DegradationRNA ExpressionRNA Gene ProductsRNA NucleasesRNA ProcessingRNA SeqRNA SplicingRNA metabolismRNA sequencingRNAseqRNaseRNase DRNase IIIRNase ORegulationResearchRibonuclease DRibonuclease Family ProteinRibonuclease IIIRibonucleasesRibonucleic AcidRibosomal RNARibosomesRoleSmall Nucleolar RNASplicingStressTranscriptTranscriptionTranscription ProcessTranslationsWorkchromatin modifierexosomegenetic conditiongenetic disordergenome mutationglobal gene expressionglobal transcript abundanceglobal transcript levelglobal transcription profilein vivomRNAmalignancyneoplasm/cancerp241posttranscriptionalrRNAresponsesnoRNAsocial roletranscriptometranscriptome sequencingtranscriptomic sequencingtranslation
Description preview
Project Summary/Abstract
RNA processing and degradation mechanisms play critical functions in the control of gene
expression. Not only do they regulate global transcripts abundance, but they also provide
quality control mechanisms to eliminate improperly processed or mis-localized transcripts.
Work in our laboratory focuses on two main aspects of…
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