grant
The contributions of N-linked glycosylation to hair cell mechanoelectrical transduction-linked proteins and auditory function
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 4 Sept 2025Deadline 3 Sept 2028
NIHUS FederalResearch GrantFY202521+ years oldActinsAdultAdult HumanAffectAmino AcidsApicalAsparagineAssayAuditoryAuditory Brainstem ResponsesBioassayBiological AssayBiological Response Modifier TherapyBiological TherapyBrainBrain Nervous SystemCell BodyCell ComponentsCell DeathCell LineCell StructureCell modelCellLineCellsCellular StructuresCellular modelCo-ImmunoprecipitationsCochleaCochlear OrganComplexCorti CellDNA mutationDataDevelopmentDiseaseDisorderDysfunctionEC 2.4EncephalonEndowmentFunctional disorderGTaseGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGlucosyltransferaseGlycansGlycopeptidase FGlycoproteinsGlycoside TransferasesHair CellsHearingHearing LossHypoacusesHypoacusisImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIn VitroIndividualIntegral Membrane ProteinIntrinsic Membrane ProteinIon ChannelIonic ChannelsIonsKnock-outKnockoutKnowledgeL-AsparagineLeadLinkMechanicsMediatingMembrane ChannelsMessenger RNAMetabolic GlycosylationMiceMice MammalsMurineMusMutagenesisMutagenesis Molecular BiologyMutant Strains MiceMutationN-Glycosidase FNeonatalNerve Impulse TransmissionNerve TransmissionNeuronal TransmissionPCDH15PCDH15 genePNGase FPathway interactionsPb elementPeptide N-glycohydrolase FPhysiopathologyPolysaccharidesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein ModificationProtein SubunitsProtein TraffickingProteinsResearchRoleSensorineural DeafnessSensorineural Hearing LossSensory Hearing LossSiteStrains Cell LinesStructureSurfaceTestingTransmembrane ProteinTransmembrane Protein GeneTransmissionWorkadulthoodaminoacidauditory pathwayaxon signalingaxon-glial signalingaxonal signalingbiological developmentbiological therapeuticbiological treatmentbiologically based therapeuticsbiotherapeuticsbiotherapycartilage link proteincell typecultured cell linedeafdeafeneddeafnessdevelopmentaldysfunctional hearingear hair cellexperimentexperimental researchexperimental studyexperimentsgenome mutationglia signalingglial signalingglycosylationglycosyltransferasehearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthearing loss therapyhearing loss treatmentheavy metal Pbheavy metal leadimprovedin vivoinsightlink proteinmRNAmechanicmechanicalmouse modelmouse mutantmurine modelmutantnecrocytosisnerve signalingneural signalingneuronal signalingneurotransmissionneurotransmitter releaseotoacoustic emissionoverexpressoverexpressionpathophysiologypathwaypolarized cellpreventpreventingprofound hearing lossprotein complexprotein expressionprotein protein interactionprotein transportprotocadherin 15protocadherin-related 15responsesensorineural hearing impairmentsocial rolesoundsugartraffickingtransmission processtreatment for hearing loss
Description preview
PROJECT SUMMARY/ABSTRACT
Cochlear hair cells are highly specialized, sound-responsive cells that contain actin-rich stereocilia at their apical
surface. The tips of stereocilia are endowed with mechanically-sensitive ion channels that open in response to
sound wave-induced deflection, leading to ion flux and hair cell depolarization, in a process…
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