grant
The circadian time of food intake and its effect on reproductive health
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 15 May 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Animal ModelAnimal Models and Related StudiesAnimalsAppetiteAquadiolBehaviorBiological ClocksBiological RhythmBirthCaloric IntakeCell NucleusChimeraChimera organismCircadian DysregulationCircadian RhythmsCompetenceConsumptionContraceptionContraceptive methodsCuesCyclicityDarknessDataDesire for foodDifferences between sexesDiffers between sexesDimenformonDiogynDiogynetsEatingEndocrine Gland SecretionEnergy IntakeEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineExposure toFailureFastingFecundabilityFecundityFemaleFertilityFertility ControlFoodFood IntakeGNRHGNRH1GNRH1 geneGoalsGonadotropin Releasing Hormone 1HealthHormonesHourHumanHypothalamic structureHypothalamusImpairmentInhibition of FertilizationInterstitial Cell Stimulating HormoneInterstitial Cell-Stimulating HormoneJet LagJet Lag SyndromeJetlagJetlag SyndromeKISS1KISS1 Metastasis SuppressorKISS1 geneKiSS-1LNRHLaboratoriesLeadLeuteinizing HormoneLightLinkLow Birth Weight InfantLuteinizing HormoneLuteinizing Hormone-Releasing HormoneLutropinMGC39258MeasuresMenstrual cycleMetabolicMetastinMiceMice MammalsMiscarriageModern ManMurineMusMutant Strains MiceNerve CellsNerve UnitNeural CellNeurocyteNeuronsNucleusNyctohemeral RhythmOutcomeOvocyclinOvocylinOvulationPartner in relationshipParturitionPathway interactionsPb elementPeriodicityPersonsPhasePhotoradiationPhysiologyPituitary Lutenizing HormonePopulationPre-Clinical ModelPreclinical ModelsPremature BirthPrematurely deliveringPreterm BirthProgynonProtocolProtocols documentationPublic HealthQOLQuality of lifeRecombinant Luteinizing HormoneReproductionReproductive BehaviorReproductive HealthReproductive PhysiologyResting PhaseRhythmicityRiskRoleRunningScheduleSex BehaviorSex DifferencesSexual ActivitySexual BehaviorSexual differencesSpeedSpontaneous abortionSystemTestingTherapeutic EstradiolTherapeutic InterventionTherapeutic LHTimeTime Zone Change SyndromeTime Zone SyndromeTwenty-Four Hour RhythmVentricularWeightaberrant tauaberrant tau proteinabnormal tauabnormal tau proteinbody clockcaloric dietary contentchimerascircadiancircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercircadian processcircadian rhythmicitydaily biorhythmday shifteating cuesendometriosisfastedfastsfeedingfitnessfood Ingestionfood consumptionfood cuesfood restrictionheavy metal Pbheavy metal leadhuman modelhunger cueshypothalamicin vivointernal clockintervention therapykisspeptinlow birth weightlow birthweightmalematemating behaviormicrotubule associated protein tau mutationmicrotubule-associated protein tau mutationmodel of animalmodel of humanmouse mutantmutant taumutant tau proteinmutation in microtubule associated protein taumutation in microtubule-associated protein tauneuronalnight shiftnight workpathogenic taupathogenic tau gene mutationpathogenic tau proteinpathological change in taupathological taupathological tau proteinpathwaypreferencepremature childbirthpremature deliverypreterm deliveryreproductivereproductive functionreproductive successsexsex activitysex based differencessex-dependent differencessex-related differencessex-specific differencessexual activitiesshift workshiftworksocialsocial rolesuccesstau abnormalitytau intronic mutationtau mutationtau pathological changeweightsτ mutation♀♂
Description preview
Abstract
Disruptions of the internal circadian clock system reduce reproductive success in both humans and animal
models. For example, shift workers have greater rates of menstrual cycle disruption and endometriosis,
reduced fertility, and have an increased risk for pre-term birth, low birth weight, and miscarriage. The
mechanisms that contribute…
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