grant
The brain as a control center for other organs during aging
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 Jan 2026Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY2026AI systemAffectAgeAgingArtificial IntelligenceBehaviorBehavioralBrachydanio rerioBrainBrain Nervous SystemBrain imagingCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCalciumCas nuclease technologyCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsChronic DiseaseChronic IllnessClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComputer ReasoningDanio rerioDataData SetDiseaseDisorderDisturbance in cognitionEncephalonGenesGeneticGenetic ScreeningGenomicsGoalsHumanImageImpaired cognitionIncrease lifespanIndividualInvestigatorsKillifishesKnock-outKnockoutLength of LifeLifeLinkLongevityMachine IntelligenceMachine LearningMedicalMiceMice MammalsModelingModern ManMolecularMultiomic DataMurineMusNatureNerve CellsNerve UnitNeural CellNeurocyteNeuromedin UNeuromedin U-25NeuronsNeuropeptidesOrganPace StimulatorsPacemakersPatternPeripheralPlayPopulationProcessProteomicsReceptor ProteinRegulationReporterReportingResearch PersonnelResearchersRestRoleSleepSubcellular ProcessSystemTechnologyTestingTherapeuticTimeTransmissionUnited StatesVertebrate AnimalsVertebratesWhole OrganismWorkZebra DanioZebra FishZebrafishage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage related pathwaysage reversalage specificage-related diseaseage-related disorderage-related impairmentaged brainagesaging associatedaging associated mechanismaging biological markeraging biomarkeraging brainaging delayaging markeraging mechanismaging pathwayaging relatedaging related mechanismaging related pathwaysaging reversalalleviate age relatedalleviate agingameliorating agingattenuate agingbehavior observationbehavioral observationbiological mechanism of agebiological pathways of ageboost longevitybrain visualizationbuild resiliencebuild resiliencycausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantchronic disordercognitive dysfunctioncognitive losscomplex datacounter age relatedcounter agingcounteract age relatedcounteract agingdecelerate agingdelay age relateddevelop resiliencedevelop resiliencydrivers of agingelongating the lifespanenhance healthspanenhance longevityenhance resilienceenhance resiliencyexperimentexperimental researchexperimental studyexperimentsextend healthspanextend life spanextend lifespanextend longevityextending healthy lifespanfacilitate resiliencefitnessfoster longevitygene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome editinggenomic editinggerodriverhealthspan extensionhigh dimensional dataimagingimprove healthspanimprove lifespanimprove longevityimprove resilienceimprove resiliencyincrease healthspanincrease resilienceincrease resiliencyinnovateinnovationinnovativeintervention enhancing longevityintervention to extend lifespanintervention to improve lifespanintervention to increase longevityintervention to prolong lifespanintervention to promote longevityknowledge of resultslife spanlifespanlifespan extending interventionlifespan extending therapieslifespan extensionlifespan improving interventionlifespan increasing interventionlifespan increasing therapieslifespan interventionlifespan prolonging interventionslifespan promoting interventionlongevity boosting interventionlongevity extending interventionlongevity interventionlongevity promoting interventionlongevity therapylongevity treatmentmachine based learningmachine learning based modelmachine learning modelmechanism regulating agingmechanisms involved in agingmolecular phenotypemortalitymultidimensional datamultidimensional datasetsmultiple omic dataneuralneural networkneuronaloptogeneticspace of agingpace of biological agingpathway involved in agingpause agingpostpone age relatedpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprolong healthspanprolong lifespanprolong longevitypromote healthspanpromote lifespanpromote longevitypromote resiliencepromote resiliencyrate of agingrate of biological agingreceptorresilience developmentresponseretards agingreverse agereverse agingreverse aging effectsreversible agingscreeningscreeningsslow agingslow down agingslow the rate of agingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspeed of agingspeed of the agingstrategy to enhance longevitystrategy to promote longevitysupport longevitytooltranscriptomicstransmission processvertebrata
Description preview
SUMMARY
The goal of this multi-investigator proposal is to determine how the brain can act as ‘neural pacemaker’ to
regulate the tempo of aging of the whole organism. Aging is a multifaceted process that alters the function of
every organ and is associated with devastating diseases. An inherent limitation to understand and target aging
has been…
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