grant
The biology of Cryptococcus neoformans melanization
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AIDSAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeActinic RaysAdvanced HIVAffectAnabolismAnimalsBasic ResearchBasic ScienceBiochemicalBiological FunctionBiological ProcessBiologyBody TissuesC neoformansC. neoformansCell BodyCell ProtectionCell WallCell modelCellsCellular biologyCellular modelCessation of lifeChemical FractionationChemicalsChronicComplexCryptococcusCryptococcus neoformansCrystallizationCytoprotectionDeathDepositDepositionDomestic HorseEffector CellElectromagnetic EnergyElectromagnetic RadiationElectromagnetic WavesElectronsEnergy harvestingEquineEquine SpeciesEquus caballusEquus przewalskiiFRACNFamilyFractionationFractionation RadiotherapyFree RadicalsFungus DiseasesGlycansGoalsHorsesHost Defense MechanismHumanImmuneImmunesImmunityImpairmentIndividualInfectionInvestigationLabelLaccaseLeadLibrariesLightLipidsLocationMacrophageMammaliaMammalsMediatingMelaninsMelanogenesisMelanosomesMetabolicMiceMice MammalsModelingModern ManMolecularMurineMusMycosesMφN-(phosphonomethyl)glycineNMR SpectrometerNMR SpectroscopyNatureNegative Beta ParticleNegatronsOrganOrganismPaperPathogenesisPathogenicityPathway interactionsPb elementPhotoradiationPigmentsPlantsPolyenesPolymersPolysaccharidesPopulationPredispositionProcessPropertyRadiationReactionResearchResistanceRoleSSNMRScienceSevere HIV DiseaseStructureSunlightSusceptibilitySystemTechniquesTestingTherapeutic FungicidesTherapeutic UsesTimeTissuesTorulaTotal RadiationUV lightUV radiationUV raysUltraviolet RaysUrishiol OxidaseVesicleVirulenceWorkabsorptionacquired drug resistanceanti-fungalanti-fungal agentsanti-fungal drugbiosynthesiscell biologycrosslinkcytoprotectivecytotoxicdrug developmentfungal infectionfungal pathogenfungi pathogenfungusfungus infectiongliphosateglyphosateheavy metal Pbheavy metal leadhost microbe associationhost microbe relationshiphost-microbe interactionshost-microbial interactionshost-microorganism interactionshuman pathogenimmunosuppressedinhibitorinsightinterdisciplinary approachliving systemmelanin inhibitormultidisciplinary approachnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetnuclear magnetic resonance spectroscopyp-Diphenol Oxidasepathogenpathogenic funguspathwaypigmentpolymerpolymericpolymerizationpreventpreventingprogramsresistantsmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolesolid state NMRsolid state nuclear magnetic resonancesun lighttargeted agenttoxic metalultra violet lightultra violet radiationultra violet raysultraviolet lightultraviolet radiationvesicle transportvesicular transport
Description preview
Cryptococcus neoformans (CN) is an important human fungal pathogen responsible for thousands of deaths
each year, primarily in immunosuppressed individuals. CN makes melanin, a pigment that performs a variety of
functions in the plant and animal kingdoms. In fungi, melanin reinforces cell walls, shields against ultraviolet
radiation and toxic…
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