grant

The Biology and Biochemistry of Lipid Transfer Protein-Regulated Phosphoinositide Signaling

Organization TEXAS A&M UNIVERSITY HEALTH SCIENCE CTRLocation COLLEGE STATION, UNITED STATESPosted 1 May 2019Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AddressAdult-Onset Diabetes MellitusBindingBinding ProteinsBiodiversityBiologicalBiological DiversityBiologyCancersCell BodyCell Communication and SignalingCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationChemicalsCodeCoding SystemDegenerative Neurologic DisordersDevelopmentDiseaseDisorderEquilibriumEukaryotaEukaryoteEukaryotic CellFamily memberGoalsGolgiGolgi ApparatusGolgi ComplexHereditaryHumanIndividualInheritedInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusKinasesKnowledgeLigand Binding ProteinLigand Binding Protein GeneLigandsLinkLipid BiochemistryLipidsMalignant MelanomaMalignant NeoplasmsMalignant TumorMammaliaMammalsMaturity-Onset Diabetes MellitusMelanomaMembraneModern ManMolecularMolecular InteractionNIDDMNerve DegenerationNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural Degenerative DiseasesNeural Stem CellNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurologic Degenerative ConditionsNeurologic DisordersNeurological Development DisorderNeurological DisordersNeuron DegenerationNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusOXYB proteinOutcomePI Transfer ProteinPhosphatesPhosphatidyl InositolPhosphatidylinositol Exchange ProteinPhosphatidylinositol Transfer ProteinPhosphatidylinositolsPhosphoinositidesPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPlayProtein BindingProteinsPtdINS4PPtdInsResearchRestRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSpecificityStable Diabetes MellitusSubcellular ProcessSystemT2 DMT2DT2DMTestingToxoplasmaTransphosphorylasesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWorkYeastsadult onset diabetesantagonismantagonistbalancebalance functionbiologicbiological signal transductionbound proteindegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalfat metabolismfungusinorganic phosphateinterestketosis resistant diabeteslipid exchange proteinlipid metabolismlipid transfer proteinmalignancymaturity onset diabetesmembrane structureneoplasm/cancernerve stem cellneural degenerationneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodegenerationneurodegenerativeneurodegenerative illnessneurodevelopmental diseaseneurogenic progenitorsneurogenic stem cellneurological degenerationneurological diseaseneuron progenitorsneuronal degenerationneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew approachesnovel approachesnovel strategiesnovel strategyobligate intracellular parasiteoxysterol binding proteinoxysterol receptorphosphatidylinositol 4-monophosphatephosphatidylinositol 4-phosphateprogenitor and neural stem cellsprogenitor biologyprogenitor cell biologyprogramssocial rolespatial and temporalspatial temporalspatiotemporalstem and progenitor biologystem cell biologytype 2 DMtype II DMtype two diabetes
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ABSTRACT/SUMMARY
The overarching objective of the proposed research is to understand how eukaryotic cells organize major

lipid signaling pathways, and how these do so in a manner that imparts both spatial and temporal specificity,

and specificity of biological outcome. The system of interest is phosphoinositide signaling and the general

question…

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The Biology and Biochemistry of Lipid Transfer Protein-Regulated Phosphoinositide Signaling — TEXAS A&M UNIVERSITY HEALT | Dev Procure