grant
The assembly and function of cellular contractile systems
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Aug 2017Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025Actin-Activated ATPaseAddressAreaBrachydanio rerioCancersCardiac Muscle CellsCardiac MyocytesCardiac beta-MyosinCardiocyteCardiovascular DiseasesCell BodyCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell divisionCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessContractile SystemCytokinesisCytoplasmic DivisionDanio rerioDevelopmental BiologyDiseaseDisorderEmbryoEmbryonicFilamentFundingFutureGenerationsGoalsHealth BenefitHeart Muscle CellsHeart myocyteIn VitroIndividualInterphaseInvestigationLifeLightM PhaseMalignant NeoplasmsMalignant TumorMechanicsMitosisMitosis StageMolecularMolecular MotorsMuscleMuscle Cell ContractionMuscle ContractionMuscle TissueMuscular ContractionMyosin AMyosin ATPaseMyosin Adenosine TriphosphataseMyosin AdenosinetriphosphataseMyosin BMyosin IIMyosin IIAMyosin IIBMyosin Type IIMyosin V3MyosinsNon-Muscle Myosin Type IIANon-Muscle Myosin Type IIBNonmuscle Myosin Type IIANonmuscle Myosin Type IIBOutputPathologic ProcessesPathological ProcessesPhosphorylationPhotoradiationProcessProductionProtein PhosphorylationProteinsReportingResearchRoleSarcomeresStress FibersSubcellular ProcessTestingVentricular Cardiac beta-MyosinVentricular beta-MyosinWorkZebra DanioZebra FishZebrafishalpha Actininbeta-Myosinbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiescardiomyocytecardiovascular disordercell cortexcell motilitycomputer based predictiondriving forceexperimentexperimental researchexperimental studyexperimentsin vivomalignancymechanicmechanicalmolecular assemblymolecular assembly/self assemblymolecular self assemblymuscle stressmuscularneoplasm/cancerparalogparalogous genepredictive modelingprogramssocial roletherapeutic targetα-Actininβ-Myosin
Description preview
1) Background and key gaps in our understanding. Cellular force generation drives processes vital for
eukaryotic life, including cell division, cell migration, and muscle contraction. Thus, the basic principles underlying
cellular force generation are central to both developmental biology and the progression of force-dependent
diseases like…
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