grant
The Aqueous Humor Outflow Resistance
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 1 May 2019Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20253-D3-D Images3-D image3-Dimensional3D3D image3D imagesAffectAlgorithmsAnteriorAqueous HumorAtomic Force MicroscopyAttenuatedBasement membraneBehaviorBiologicalBiomechanicsBlindnessBody TissuesCLG4CLG4ACell BodyCell-Extracellular MatrixCellsChargeComplexCranial Nerve IICranial Nerve II DiseasesCranial Nerve II DisorderDevelopmentDexamethasoneDrug ModelingsECMElementsEndothelial CellsEndotheliumExhibitsExtracellular MatrixEyeEye diseasesEyeballFaceForce MicroscopyFoundationsFuture GenerationsGiant CellsGlaucomaGlycoprotein GP-2GoalsHealth CareHumanImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInterventionIntraocular FluidIntraocular PressureKnowledgeLamininLiquid substanceMMP14MMP14 geneMMP2MMP2 geneMMP3MMP3 geneMMPsMT1-MMPMaintenanceMapsMatrix Metalloproteinase-14Matrix MetalloproteinasesMechanicsMembrane-Type Matrix Metalloproteinase 1Membrane-Type Matrix Metalloproteinase 14MethodologyMethodsModelingModern ManMolecularMolecular TargetMovementMultinucleated Giant CellsNeural-Optical LesionOcular TensionOptic NerveOptic Nerve DiseasesOptic NeuropathyOrgan CultureOrgan Culture TechniquesOutcomePathway interactionsPatternPerfusionPersonsPhysiologic Intraocular PressurePlayPolykaryocytesProcessPropertyProteoglycanPublicationsRegulationResearchResistanceResolutionRisk FactorsSL-1STMYSTMY1STR1Scanning Electron MicroscopyScanning Force MicroscopySchlemm's canalScientific PublicationSecond Cranial NerveSecond Cranial Nerve DiseasesSightStretchingStructureStructure of sinus venosus of scleraSuggestionSurfaceSyncytiumSystemTBE-1TechniquesTestingThickThicknessThree-Dimensional ImageTissuesTzanck CellVacuoleVariantVariationVisionWorkaqueousattenuateattenuatesbiologicbiomechanic modelingbiomechanic simulationbiomechanicalbiomechanical analysesbiomechanical analysisbiomechanical assessmentbiomechanical characterizationbiomechanical evaluationbiomechanical measurementbiomechanical modelbiomechanical modelingbiomechanical profilingbiomechanical simulationbiomechanical testbody movementdensitydevelopmentaleye disorderfacesfacialfascinatefluidfluid flowglaucomatousimagingin vitro Organ Culturingin vitro vertebrate organ culturinginhibitorinnovateinnovationinnovativeinsightintra-ocular pressureliquidmechanicmechanicalmetermicroscope imagingmicroscopic imagingmicroscopy imagingnerve damagenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachocular diseaseocular disorderophthalmopathyoptic nerve disorderpathwaypressureresistance mechanismresistantresistant mechanismresolutionsresponsesecond cranial nerve disordersimulationsuper high resolutionsuperresolutionthree dimensionalultra high resolutionversicanvirtualvision lossvisual functionvisual loss
Description preview
Project Summary
Glaucoma stands as a formidable adversary in the realm of ocular diseases, chiefly because elevated intraocular
pressure (IOP) is both its primary risk factor and the sole controllable parameter. The regulation of IOP is a
complex ballet, orchestrated primarily in the outflow pathway by juxtacanalicular (JCT) and Schlemm’s canal…
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