grant
The Aging Pituitary/Gonadal Axis
Organization WICHITA STATE UNIVERSITYLocation WICHITA, UNITED STATESPosted 15 Apr 2009Deadline 31 May 2028
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPATAC sequencingATAC-seqATACseqAddressAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AffectAgeAgingAgonistAlternate SplicingAlternative RNA SplicingAlternative SplicingAmericanAntralArrestinsAssay for Transposase-Accessible Chromatin using sequencingBackBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBiochemicalBiologicalBloodBlood Reticuloendothelial SystemBody TissuesBone DensityBone Mineral DensityCREBCREB1CREB1 geneCUT&RUNCannot achieve a pregnancyCell BodyCell Communication and SignalingCell LineCell SignalingCell membraneCellLineCellsChorionic Gonadotropin ReceptorsCirculationCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCombining SiteConfusionConfusional StateCorpus Luteum HormoneCoupledCouplingCryo-electron MicroscopyCryoelectron MicroscopyCyclic AMPCytoplasmic MembraneDelta4-pregnene-3,20-dioneDevelopmentDifficulty conceivingDisparateDorsumELISAElderlyElectron CryomicroscopyEndocrine Gland SecretionEngineeringEnzyme GeneEnzyme-Linked Immunosorbent AssayEnzymesEstrogensEvaluationExhibitsFSH ReceptorsFecundabilityFecundityFeedbackFemaleFemale Genital SystemFertilityFertility AgentsFertility DrugsFollicle Stimulating HormoneFollicle Stimulating Hormone ReceptorFolliculostatinFollitropinFundingG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ModelsGenetic TranscriptionGenitourinaryGenitourinary systemGlycansGlycoproteinsGoalsGreen Fluorescent ProteinsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHPO axisHealthHormone ReceptorHormonesHumanHypophysisHypophysis CerebriICSH ReceptorsImpairmentInfertilityInfertility AgentsInfertility DrugsInhibin HormoneInjectionsInterstitial Cell-Stimulating Hormone ReceptorsIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLH ReceptorsLaboratoriesLiftingLigand BindingLinkLipidsLocationLuteinizing Hormone ReceptorsLutropin ReceptorsMeasuresMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMenstrual cycleMental ConfusionMetabolic GlycosylationMiceMice MammalsModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMorbidityMorbidity - disease rateMuellerian inhibiting hormoneMullerian-inhibiting factorMurineMusN-Glycosylation SiteNull MouseObesityOligosaccharidesOrganismOsteoclastsOsteoporosisOutcomeOutcomes ResearchOvarianOvarian Granulosa CellOvarian agingOvaryPathway interactionsPatternPerimenopausalPerimenopausePhysiologicPhysiologicalPituitaryPituitary GlandPituitary Nervous SystemPlasma MembranePlayPolysaccharidesPregn-4-ene-3,20-dionePregnenedionePreparationProcessProgesteroneProtein Hormone ReceptorRNA ExpressionRNA SeqRNA sequencingRNAseqReactive SiteReagentReceptor ActivationReceptor ProteinReproductionResearchRetinal S-AntigenRoleRotationSideSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSteroid CompoundSteroid ReceptorsSteroidsStrains Cell LinesStructureSurface ProteinsSystemTSH ReceptorsTherapeutic EstrogenTherapeutic HormoneTherapeutic ProgesteroneThyroid Stimulating Hormone ReceptorsThyrotropin ReceptorTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceTransgenic OrganismsUrogenitalUrogenital SystemUterine BleedingUterine hemorrhageVariantVariationWhole OrganismWomanadenosine 3'5' monophosphateadiposityadvanced ageage associatedage associated effectsage correlatedage dependentage effectage linkedage relatedage related effectsage specificagesaging effectaging human ovaryaging ovaryanti-mullerian factoranti-mullerian hormoneassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiologicbiological signal transductionbonebone lossbone masscAMPcAMP Response Element-Binding Protein 1conformationconformationalconformational stateconformationallyconformationscorpulencecryo-EMcryoEMcryogenic electron microscopycultured cell linedevelopmentalenzyme linked immunoassayfemale reproductive body systemfemale reproductive organ systemfemale reproductive systemfertility assistancefertility cessationfertility improvementfertility interventionsfertility lossfertility medicinefertility promoting drugfertility treatmentgeriatricglycosylationgranulosa cellgynecologic body systemgynecologic organ systemhuman femalehypothalamic pituitary ovarian axisimpact of ageimprove fertilityimprovedin vivoincrease fertilityinfertileinfertility treatmentinfluence of ageinhibinliving systemmembrane structuremenopause transitionmonomermouse geneticsmouse modelmullerian inhibiting substancemullerian regression factormullerian-inhibiting hormonemullerian-inhibitory substancemurine modelnanodiskold ageolder womenovarian senescenceovulatory senescencepathwayperi-menopausalperi-menopauseplasmalemmapreparationsprogramspsychologicpsychologicalreceptorreproductivereproductive agingreproductive cell senescencereproductive senescenceresponsescRNA sequencingscRNA-seqsenior citizensingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestructural biologytraffickingtranscription factortranscriptome sequencingtranscriptomic sequencingtransgenictransition to menopausetransitional menopausetranslational opportunitiestranslational potentialuterus bleedingvasomotor symptomsyoung womanyounger age♀
Description preview
Project Summary/Abstract - Overall
This integrated program project was pursuant to the discovery of naturally occurring, partially glycosylated
follicle-stimulating hormone (FSH) glycoforms by the Bousfield laboratory. Two of these glycoforms possessed 3
of 4 N-glycans, exhibited greater biological activity, and were more abundant than…
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