grant
The Aging Autistic Brain: Multi-modal imaging to predict accelerated memory decline
Organization ARIZONA STATE UNIVERSITY-TEMPE CAMPUSLocation SCOTTSDALE, UNITED STATESPosted 7 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAD/HDADHDASDAccelerationActive Follow-upActivities of Daily LivingActivities of everyday lifeAddressAdultAdult HumanAgeAgingAmentiaAmmon HornAttention deficit hyperactivity disorderAutismAutistic DisorderBiologic ModelsBiological MarkersBiological ModelsBrainBrain Nervous SystemCaringCell Communication and SignalingCell SignalingCerebral PalsyChildChild YouthChildren (0-21)CognitiveCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalCornu AmmonisDWI (diffusion weighted imaging)DWI-MRIDataDementiaDevelopmentDiagnosisDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDisturbance in cognitionEOADEarly Infantile AutismEarly Onset Alzheimer DiseaseElderlyEncephalonEpisodic memoryExerciseFunctional MRIFunctional Magnetic Resonance ImagingFundingFutureGenomicsGoalsGrantHippocampusHydrogen OxideImaging ProceduresImaging TechnicsImaging TechniquesImmediate MemoryImpaired cognitionInfantile AutismIntellectual disabilityIntellectual functioning disabilityIntellectual limitationInterventionIntracellular Communication and SignalingInvestigationKanner's SyndromeKnowledgeLeadLeannessLeast SquaresLeast-Squares AnalysesLeast-Squares AnalysisLinkLiteratureLong-term cohortLongitudinal cohortMR ImagingMR TomographyMRIMRI ScansMRI biomarkerMRI markerMRIsMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMapsMeasuresMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMemory LossMethodsModalityModel SystemModelingMolecularMonitorMultimodal ImagingNMR ImagingNMR TomographyNational Institutes of HealthNerve DegenerationNeurobiologyNeuron DegenerationNuclear Magnetic Resonance ImagingOutcomePETPET ScanPET imagingPETSCANPETTPaperParticipantPatternPb elementPersonsPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrecision carePredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPrevalencePublic HealthPublishingQOL improvementRad.-PETReporterResearchResearch DesignRisk FactorsRisk-associated variantRoleSeriesShort-Term MemorySignal TransductionSignal Transduction SystemsSignalingStudy TypeStudy modelsSynapsesSynapticTestingThinnessTimeUnited States National Institutes of HealthVisitVisualVisuospatialWaterZeugmatographyaccelerated agingaccelerated biological ageaccelerated biological agingactive followupadult with ASDadult with autismadult with autism spectrum disorderadulthoodadults on the autism spectrumadults on the spectrumadvanced ageage accelerationage associatedage correlatedage dependentage linkedage relatedage related pathwaysage specificaged brainagesaging associated diseaseaging associated disordersaging associated mechanismaging brainaging mechanismaging pathwayaging related diseaseaging related disordersaging related mechanismaging related pathwaysautism spectral disorderautism spectrum disorderautisticautistic adultautistic spectrum disorderbio-markersbiologic markerbiological mechanism of agebiological pathways of agebiological signal transductionbiomarkerbiomarker developmentbiomarker identificationcardiovascular healthclinical predictorscognitive dysfunctioncognitive losscohortdMRIdaily living functiondaily living functionalitydementia riskdevelop therapydevelopmentaldiffusion tensor imagingdisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingearly onset ADearly onset Alzheimer'sexecutive controlexecutive functionfMRIfollow upfollow-upfollowed upfollowupfunctional abilityfunctional capacitygeriatricheavy metal Pbheavy metal leadhemodynamicshigh riskhippocampalidentification of biomarkersidentification of new biomarkersimprovements in QOLimprovements in quality of lifein vivoindividualized careindividualized patient careintellectual and developmental disabilityinterestintervention developmentkidslife time costlifetime costlimited intellectual functioninglong-term memorymagnetic resonance imaging biomarkermagnetic resonance imaging markermalleable riskmarker identificationmechanism regulating agingmechanisms involved in agingmemory declinemethods to study multiple-level influencesmid lifemid-lifemiddle agemiddle agedmidlifemild cognitive disordermild cognitive impairmentmodifiable riskmulti-level analysismulti-level modelmulti-modal imagingmulti-modalitymulti-modality imagingmultilevel analysismultilevel modelmultilevel modelingmultimodalitymultimodality imagingneural controlneural degenerationneural regulationneurobiologicalneurodegenerationneurodegenerativeneurological degenerationneuromodulationneuromodulatoryneuronal degenerationneuroregulationnon-invasive imagingnoninvasive imagingnovelolder adultolder adulthoodpathway involved in agingpersonalized carepersonalized patient carepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprecision medicineprecision-based medicinequality of life improvementrisk allelerisk factor for dementiarisk for dementiarisk generisk genotyperisk locirisk locusrisk variantsegregationsenior citizensocial rolestudy designsubstantia albasynapsetherapy developmenttreatment developmentverbalvisual spatialwhite matterworking memoryyoungster
Description preview
Project Summary/Abstract
Middle-age adults with autism spectrum disorder (ASD) have a 2.6x higher risk for early-onset Alzheimer’s
disease and other dementias than non-ASD. In children, ASD prevalence is ~2%. Since ASD is a lifelong
condition, there will soon be a large population of elderly with an ASD diagnosis (~700,000 in the U.S within
the…
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