grant
Th2 Memory in Chronic Type 2 Inflammation
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 5 Feb 2026Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026Aberrant TissueAcuteAdoptive TransferAirway Hyper-responsivenessAllergicAllergic DiseaseAlternariaAnimal ModelAnimal Models and Related StudiesAntigensAsthmaAtlasesBasic ResearchBasic ScienceBody TissuesBronchial AsthmaCancersCell BodyCellsCellular Metabolic ProcessChoristomaChronicChronic PhaseChronic SinusitisClinicalDataDiseaseDisease ProgressionDisorderDissectionEctopic TissueEnhancer-Binding Protein GATA3EquilibriumFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFutureGATA-3 factorsGATA-3 proteinGATA-Binding Protein 3GATA3GATA3 geneGATA3 proteinGATA3 transcription factorGene ExpressionGene TranscriptionGeneHomologGenetic ModelsGenetic TranscriptionGlucocorticoidsGoalsHeterotopic TissueHomologHomologous GeneHomologueHouse Dust MitesHousedust MitesHumanImageImmuneImmune responseImmunesImmunologyIn SituIn VitroInflammationInflammatoryInformaticsKnowledgeLineage TracingLong-term infectionLungLung ParenchymaLung Respiratory SystemLung TissueLymphatic cellLymphocyteLymphocyticMHC ReceptorMaintenanceMajor Histocompatibility Complex ReceptorMalignant NeoplasmsMalignant TumorMemoryMetabolicMiceMice MammalsModelingModern ManModificationMultiple PolypsMultipotent Stem CellsMurineMusNamesNasalNasal Passages NoseNoseOutcomePathologyPathway interactionsPeptidesPhenotypePopulationPositionPositioning AttributeProgenitor CellsPyroglyphidaeRNA ExpressionReceptor SignalingRegulatory T-LymphocyteResolutionRespiratory System, Nose, Nasal PassagesRestRoleSamplingSamter's triadStem Cell DevelopmentStem Cell likeStructure of parenchyma of lungSurvey InstrumentSurveysSystemT cell receptor repertoire sequencingT cell receptor sequencingT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTSLPTSLP geneTestingTherapeuticThymic Stromal LymphopoietinTimeTissuesTranscriptionTregairway epithelium inflammationairway hyper-reactivityairway hyperactivityairway hyperreactivityairway hyperresponsivenessairway hypersensitivityairway inflammationalleviate symptomameliorating symptomaspirin-exacerbated respiratory diseaseaspirin-induced asthmaasthma modelbalancebalance functioncancer immunologycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell metabolismcellular lineage mappingcellular lineage trackingcellular metabaolismchronic infectionchronic rhinosinusitiscomparativedecrease symptomdesigndesigningexhaustexhaustionexperienceexperimentexperimental researchexperimental studyexperimentsfewer symptomsflow cytophotometryglobal gene expressionglobal transcription profilehigh dimensionalityhost responsehuman diseasehuman modelhuman progenitorhuman stem cellshuman tissueimagingimmune system responseimmunogenimmunoresponsein vivolymph cellmalignancymodel of animalmodel of humanmouse allergenmouse modelmultiomicsmultiple omicsmultipotent progenitormultipotent progenitor cellmurine modelnamenamednamingneoplasm immunologyneoplasm/cancernovelpanomicspathwaypersistent infectionpolyposisprogenitorprogenitor capacityprogenitor cell developmentprogenitor cell likeprogenitor cell maintenanceprogenitor cell poolprogenitor cell populationprogenitor developmentprogenitor maintenanceprogenitor poolprogenitor populationprogenitor-likerecidivismreduce symptomsregulatory T-cellsrelieves symptomsresolutionsrespiratory inflammationrespiratory tract inflammationresponsescRNA sequencingscRNA-seqself-renewself-renewalsensitizing antigensingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestemstem and progenitor cell developmentstem and progenitor cell populationstem cell characteristicsstem cell maintenancestem cell poolstem cell populationstem cellsstem-likestemnesssymptom alleviationsymptom reductionsymptom relieftargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetissue progenitortissue specific progenitor cellstissue specific stem cellstissue stem cellstranscriptometranscriptomicstranslational studytumor immunology
Description preview
Project Summary
Immune responses to cancer and chronic infection often collapse, corresponding to progression of disease.
This collapse is not inevitable, however, and both natural and therapeutic exceptions have been shown occur
through re-invigoration of a stem-like progenitor population of T cells. It remains unknown how aberrant type 2…
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