grant
Temporal lobe epileptogenesis
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025Ammon HornAnimal ModelAnimal Models and Related StudiesAxonBlocking AntibodiesBrainBrain Nervous SystemCell BodyCellsCharacteristicsCommon Rat StrainsCompensationConnector NeuronCornu AmmonisDataDentate FasciaDorsalEDRF SynthaseEEGElectroencephalogramElectroencephalographyEncephalonEndothelium-Derived Growth Factor SynthaseEpilepsyEpileptic SeizuresEpilepticsEpileptogenesisFascia DentataFrequenciesGoalsGuanylyl Cyclase-Activating Factor SynthaseGyrus DentatusHippocampusHumanInfusionInfusion proceduresInjuryIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronKnowledgeLabelMeasuresMethodsModern ManMolecularNO SynthaseNitric Oxide SynthaseNitric-Oxide SynthetaseOsmosisOutcomeOutputPathologicPatientsPersonsPilocarpinePumpRatRats MammalsRattusSea LionsSealionsSeizure DisorderSeizuresSliceSynapsesSynapticTelemetriesTelemetryTemporal LobeTemporal Lobe EpilepsyTestingUnited StatesWhole-Cell Recordingsbiocytinbiotinyl L lysinebrain celldentate gyruseffective therapyeffective treatmentepilepsiaepilepsy monitoringepilepsy recordingepilepsy trackingepileptic monitoringepileptic recordingepileptiform monitoringepileptiform recordingepileptiform trackingepileptogenicepileptogenic monitoringgranule cellhippocampalimmunocytochemistryinfusionsinjuriesmodel of animalmouse modelmurine modelneural cell bodyneuronal cell bodyneuropathologicneuropathologicalneuropathologypostsynapticpreventpreventingseizure detectionseizure monitoringseizure recordingseizure trackingsomasynapsetelemetrictemporal cortex
Description preview
Project Summary / Abstract
Our ultimate goal is to discover causes of seizures in patients with temporal lobe epilepsy. The primary
objective of the proposed project is to generate new data on reelin-positive interneurons in the dentate gyrus
and test whether their loss is epileptogenic. The specific aims are to: Identify the type of reelin…
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