grant
Telomere uncapping epigenetically reprograms a stress response and longevity pathway
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 15 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20250-11 years oldAbscissionAffectAgeAgingArsenicBasal Transcription FactorBasal transcription factor genesBase PairingBindingBiological FunctionBiological ProcessBiologyC elegansC. elegansC.elegansCaenorhabditis elegansCancersCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationChildChild YouthChildren (0-21)Chromosome ArmCopperCoupledCu elementDNADNA DamageDNA InjuryDNA mutationDataDefectDeoxyribonucleic AcidDouble-Stranded DNAElderlyEmbryoEmbryonicEnhancer ElementsEnvironmentEnvironmental ToxinEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExcisionExtirpationFuture GenerationsGametesGene Action RegulationGene ExpressionGene Expression RegulationGene InactivationGene RegulationGene Regulation ProcessGene SilencingGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic ChangeGenetic Enhancer ElementGenetic defectGenetic mutationGenomicsGerm CellsGerm-Line CellsHeritabilityHumanIncrease lifespanIndividualInflammationIntervening SequencesIntestinalIntestinesIntronsLarvaLengthLength of LifeLinkLongevityLongevity PathwayMalignant NeoplasmsMalignant TumorModelingModern ManMolecular InteractionMutateMutationNuclearParentsPhenotypePost-Transcriptional Gene SilencingProteinsRNA InterferenceRNA SilencingRNAiRemovalReproductive CellsResistanceRoleSequence-Specific Posttranscriptional Gene SilencingSex CellSomatic CellStressStructureSurgical RemovalTEBPTelomeraseTelomere CappingTelomere End-Binding ProteinTelomere-Binding ProteinsTestingToxic Environmental AgentsToxic Environmental SubstancesTranscription Factor Proto-OncogeneTranscription factor genesTransmissionWorkadult youthadvanced ageagesarsenicsbiological adaptation to stressboost longevitybowelcell typeds-DNAdsDNAelongating the lifespanenhance longevityenhancer sequenceenvironmental stressesenvironmental stressorenvironmental toxicantepigeneticallyexperimentexperimental researchexperimental studyexperimentsextend life spanextend lifespanextend longevityfitnessfoster longevitygene functiongenetic enhancer sequencegenome mutationgenome sequencinggeriatricimprove lifespanimprove longevityimprovedinitial cellinsightinterstitialkidslife spanlifespanlifespan extensionlong read seqlong-read sequencinglong-read transcript sequencinglongevity genemalignancymutantneoplasm/cancernovelparentperceived stressperception of stresspro-agingprogeronicprogramsprolong lifespanprolong longevitypromote agingpromote lifespanpromote longevityreaction; crisisresectionresistantresponseself-reported stresssenescencesenescentsenior citizensexual cellsocial rolestress perceptionstress responsestress; reactionsupport longevitytelomeretranscription factortranscriptional silencingtransmission processyoung adultyoung adult ageyoung adulthoodyoungster
Description preview
Summary
Interstitial Telomere Sequences (ITS tracts) are degenerate telomere repeat tracts found on metazoan
chromosome arms whose functional significance is not known. We propose to develop a new paradigm in the
field of telomere biology, by demonstrating a telomere binding protein in somatic cells regulates a suite of
stress response and…
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