grant
Targeting the neural circuits controlling negative reinforcement to prevent alcohol seeking in males and females
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 15 Mar 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AbstinenceAffectiveAffinity ChromatographyAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAnimalsAversive StimulusBehaviorBehavioralBrain regionCell BodyCellsConsumptionD1 receptorDREADDsDataDifferences between sexesDiffers between sexesDopamine D1 ReceptorETOH levelEducationEducational aspectsEtOH drinkingEtOH useFemaleFutureGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingHumanIndividualLearningMachine LearningMediatingMiceMice MammalsModelingModern ManMolecularMurineMusNegative ReinforcementsNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNucleus AccumbensOpticsOutcomePatternPerformancePhenotypePhysiologicPhysiologicalPopulationProcessProteomePsychological reinforcementRNA SeqRNA sequencingRNAseqReinforcementResearchRibosomesRodentRodentiaRodents MammalsRoleSex DifferencesSexual differencesStimulusSystemTranscript Expression AnalysesTranscript Expression AnalysisTranslatingWorkabstaining from alcoholabstaining from ethanolabstinence from alcoholabstinence from ethanolaffinity purificationalcohol abstinencealcohol cuealcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol levelalcohol measurementalcohol product usealcohol related cuealcohol related researchalcohol researchalcohol seekingalcohol seeking behavioralcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeanalyze gene expressionawakebehavior phenotypebehavioral phenotypingbinge alcohol consumptionbinge drinkingbiological sexcell typedesigner receptors exclusively activated by designer drugsdrinkingendomicroscopyendophenotypeepisodic drinkingethanol abstinenceethanol consumptionethanol cueethanol drinkingethanol exposedethanol exposureethanol ingestionethanol intakeethanol measurementethanol product useethanol researchethanol seekingethanol useethanol use disorderethanol-seeking behaviorethyl alcohol measurementsexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolgene expression analysisgene expression assayglobal gene expressionglobal transcription profilehuman datain vivomachine based learningmalemicroendoscopynegative affectnegative affectivityneuralneural circuitneural circuitryneurocircuitryneuronalnext generationopticalpreventpreventingresponsesexsex based differencessex dimorphismsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsocial rolesynaptic circuitsynaptic circuitrytooltranscriptional profilingtranscriptometranscriptome sequencingtranscriptomic sequencing♀♂
Description preview
ABSTRACT
Alcohol use disorder (AUD) is characterized by high levels of alcohol intake followed by aversive
negative affective states when individuals cease consumption. In certain individuals suffering from
AUD, alcohol taking and seeking is, in many cases, thought to be motivated by negative
reinforcement, where individuals continue consuming…
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