grant
Targeting the Giardia secretome to reduce growth impairment
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 8 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY20260-11 years old2 year old2 years of age7S Gamma GlobulinActive ImmunizationActive vaccinationAgeAge MonthsAntibodiesAntibody ResponseAntibody TherapyAntigensAssayAutomobile DrivingBioassayBiological AssayBiological MarkersBlood SerumBody Weight decreasedCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCaCo2Caco-2 CellsCaspaseCaspase GeneCell BodyCell Communication and SignalingCell Culture TechniquesCell LineCell SignalingCell-Death ProteaseCellLineCellsChildChild DevelopmentChild SupportChild YouthChildhoodChildren (0-21)Clustered Regularly Interspaced Short Palindromic Repeats interferenceCo-cultureCocultivationCocultureCoculture TechniquesCognitiveCystCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesDataDevelopmentDiseaseDisease OutcomeDisorderDysfunctionEconomic IncomeEconomical IncomeEndopeptidase-Activated ReceptorsEngineeringEpithelial CellsEsteroproteasesExhibitsFoundationsFunctional disorderFutureG lambliaG. lambliaGI colonizationGeneralized GrowthGiardiaGiardia intestinalisGiardia lambliaGiardiasisGnotobioticGnotobioticsGrowthGrowth and DevelopmentGrowth and Development functionGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHumanICE-like proteaseIgAIgGImmune responseImmunizationImmunodeficient MouseImmunoglobulin AImmunoglobulin GImpairmentIn VitroIncomeIndividualInfant and Child DevelopmentInfectionInfection preventionInjuryInterventionIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityIntestinesIntracellular Communication and SignalingKnowledgeLMICLambliaLamblia intestinalisLambliasisLinkLongitudinal StudiesLongitudinal SurveysMalnutritionMeasuresMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsModelingModern ManMurineMusNutritional DeficiencyOutcomeParasitesPassive ImmunizationPathogenesisPathogenicity FactorsPathologyPathway interactionsPeptidasesPeptide HydrolasesPermeabilityPhysiologicPhysiologicalPhysiopathologyPopulationPrevent infectionProtease GeneProtease-Activated ReceptorsProteasesProtein SecretionProteinase-Activated ReceptorsProteinasesProteinsProteolytic EnzymesPublic HealthPublishingRecombinantsRecoveryRepressionRoleSerine EndopeptidasesSerine ProteaseSerine Protein HydrolasesSerine ProteinasesSerologySerumSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStrains Cell LinesSurface ProteinsSystemTechniquesTestingTissue GrowthUndernutritionVaccinesVirulence FactorsWeight LossWeight ReductionWild Type MouseWorkage 2age 2 yearsaged 2 yearsaged two yearsagesantagonismantagonistantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentbio-markersbiobankbiologic markerbiological signal transductionbiomarkerbiorepositorybody weight lossbowelcell culturecell culturescohortcultured cell linecystein proteasecystein proteinasecysteine endopeptidasedevelopmentaldietary deficiencydrivingdruggable targetearly childhoodfield based datafield learningfield studyfield testgastrointestinal tract colonizationgut colonizationhigh riskhost responsehypoimmunityimmune deficiencyimmune system responseimmunodeficiencyimmunogenimmunogenicityimmunoreactivityimmunoresponsein vitro Modelincomesinjuriesintestinal barrierintestinal colonizationintestinal epitheliumintestinal mucosal barrierkidslong-term studylongitudinal outcome studieslongitudinal research studylow and middle-income countriesmalnourishedmonolayermouse modelmurine modelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderontogenypassive vaccinationpathogenpathophysiologypathwaypediatricpreservationrepressing CRISPR-dCas9 systemresponseshRNAshort hairpin RNAsmall hairpin RNAsocial roletherapeutic targettwo year oldtwo years of agewildtype mousewt-lossyoungster
Description preview
Giardia lamblia (Giardia) causes >300 million infections annually worldwide. In multi-site field studies Giardia
consistently associates with impaired child growth and has also been associated with other cognitive
developmental impairments in early childhood.
The exact mechanisms, and specifically, which virulence factors are responsible for…
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