grant

Targeting specific MicroRNA to alleviate Alzheimer’s Disease pathobiology

Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 May 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202521+ years old3' Untranslated Regions3'UTRAD dementiaAD pathologyAD related dementiaADRDAbeta clearanceAdultAdult HumanAgeAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's brainAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease brainAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAmentiaAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β clearanceAmyloid β-PeptideAmyloid β-ProteinAstrocytesAstrocytusAstrogliaAutophagocytosisAutoregulationAβAβ clearanceBasal Transcription FactorBasal transcription factor genesBehaviorBindingBody TissuesBrainBrain Nervous SystemCD11bCR3ACell BodyCellsChronicCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalD-MannoseDataDefectDementiaDepositDepositionDeteriorationDisturbance in cognitionDown-RegulationEncephalonEquilibriumEukaryotic CellExposure toFunctional RNAGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionHomeostasisHortega cellHumanHyperactivityITGAMITGAM geneImmuneImmunesImpaired cognitionImpairmentIn VitroIndividualIngestionInjectionsKnowledgeMAC1AMO1AMT-bound tauMannopyranoseMannopyranosideMannoseMediatingMemoryMemory LossMiceMice MammalsMicroRNAsMicrogliaModelingModern ManMolecularMolecular InteractionMurineMusNerve CellsNerve DegenerationNerve UnitNeural CellNeuritic PlaquesNeurocyteNeuron DegenerationNeuronsNoncoding RNANontranslated RNAPeptidesPhasePhysiological HomeostasisPreventative measurePreventive measurePrimary Senile Degenerative DementiaProcessProductionProteinsPublishingRNA ExpressionRapamuneRapamycinReceptor ProteinReportingRoleSamplingSenile PlaquesSignal PathwaySirolimusTestingTherapeutic InterventionTissuesTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesUntranslated RNAUpregulationVacuolea beta peptidea-beta peptide clearanceabetaabeta accumulationabeta aggregationabeta depositionabeta peptide clearanceadulthoodage associatedage correlatedage dependentage linkedage relatedage specificagesamyloid betaamyloid beta accumulationamyloid beta aggregationamyloid beta clearanceamyloid beta depositionamyloid beta peptide clearanceamyloid beta plaqueamyloid β accumulationamyloid β aggregationamyloid β depositionamyloid-b plaqueamyloid-b proteinastrocytic gliaautophagyaβ accumulationaβ aggregationaβ depositionaβ plaquesbalancebalance functionbeta amyloid fibrilbrain cellcognitive dysfunctioncognitive losscored plaquediffuse plaqueexperimentexperimental researchexperimental studyexperimentsextracellulargitter cellhuman diseaseimprovedin vivoingestinhibition of autophagyintervention therapymembermemory declinemesogliamiRNAmicroglial cellmicrogliocytemicrotubule bound taumicrotubule-bound taumouse modelmurine modelnano labelnano particlenano-sized particlenanolabelnanoparticlenanosized particleneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuron toxicityneuronalneuronal degenerationneuronal toxicityneuroprotectionneuroprotectiveneurotoxicitynew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnoncodingnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetpatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseaseperivascular glial cellpreventpreventingprimary degenerative dementiareceptorresponsesenile dementia of the Alzheimer typesexsocial rolesoluble amyloid precursor proteintautau Proteinstau factortherapeutic evaluationtherapeutic targettherapeutic testingtranscription factorτ Proteins
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Targeting microglia to alleviate Alzheimer’s Disease pathobiology
Summary
Alzheimer’s disease (AD) is the most common cause of age-related dementia leading to irreversible
neurodegeneration and cognitive decline with no cure or effective preventive measures. Autophagy is a
conserved, cell response found in all eukaryotic cells. Several studies in…

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Targeting specific MicroRNA to alleviate Alzheimer’s Disease pathobiology — OHIO STATE UNIVERSITY | UNITED STATES | May | Dev Procure