grant
Targeting PD-1 Pathway for Functional Cure of AIDS
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAIDS/HIVAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressAdenoviridaeAdenovirusesAnimalsAntigenic DeterminantsAntigensBindingBinding DeterminantsBloodBlood Reticuloendothelial SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChimpChimpanzeeChronicClass I GenesCo-StimulatorCombination VaccinesCombined Modality TherapyCombined VaccinesCostimulatorDNA/MVA vaccineDataDetectionDisease remissionEffector CellEpidermal Thymocyte Activating FactorEpitopesFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesGerminal CenterGoalsGrantGranzymeHIVHIV/AIDSHaplotypesHeterogeneityHumanHuman Immunodeficiency VirusesIL-2IL2 ProteinImmune mediated therapyImmunityImmunologically Directed TherapyImmunotherapyInfectionInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-2Interleukine 2Interleukine 2 PrecursorInterleukine IIInterruptionInvestmentsLAV-HTLV-IIILCM VirusesLCMVLYT3LaboratoriesLymph Node Reticuloendothelial SystemLymph node properLymphadenopathy-Associated VirusLymphatic nodesLymphocyte Mitogenic FactorLymphocytic choriomeningitis virusM mulattaM. mulattaMHC Class IMHC Class I GenesMacacaMacaca mulattaMacaca rhesusMacaqueMiceMice MammalsMitogenic FactorModelingModern ManMolecular InteractionMonitorMultimodal TherapyMultimodal TreatmentMurineMusPD 1PD-1PD-1 antibodyPD-1 blockadePD-1 checkpoint pathwayPD-1 pathwayPD-1 signaling pathwayPD1PD1 antibodyPD1 blockadePD1 checkpoint pathwayPD1 pathwayPD1 signaling pathwayPathway interactionsRNA SeqRNA sequencingRNAseqRemissionRhesus MacaqueRhesus MonkeySIVSafetySimian Immunodeficiency VirusesSortingStructure of germinal center of lymph nodeSubcellular ProcessT cell growth factorT cell responseT-Cell Growth FactorT-Cell Stimulating FactorT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTestingTherapeuticThymocyte Stimulating FactorTreatment EfficacyVAC-TXVaccinatedVaccinationVaccine TherapyVaccinesViralViral reservoirViremiaVirus reservoirVirus-HIVWorkaPD-1aPD1anti programmed cell death 1anti programmed cell death protein 1 checkpoint pathwayanti programmed cell death protein 1 pathwayanti programmed cell death protein 1 signaling pathwayanti-PD-1anti-PD-1 Abanti-PD-1 antibodiesanti-PD-1 blockadeanti-PD-1 monoclonal antibodiesanti-PD1anti-PD1 Abanti-PD1 antibodiesanti-PD1 blockadeanti-PD1 monoclonal antibodiesanti-programmed cell death protein 1anti-programmed cell death protein 1 antibodiesanti-programmed death-1 antibodyantiPD-1antiretroviral therapyantiretroviral treatmentcombination therapycombined modality treatmentcombined treatmentcytokine based immunotherapycytokine based therapycytokine immunotherapycytokine therapycytokine treatmenteffective therapyeffective treatmentexhaustexhaustionflow cytophotometryimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimprovedintervention efficacylymph glandlymph nodeslymphnodeslymphocyte pore-forming proteinmulti-modal therapymulti-modal treatmentnon vaccinatednot vaccinatedpathwayperforinprogrammed cell death 1programmed cell death protein 1programmed death 1programsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2successsynergismsystemic lupus erythematosus susceptibility 2therapeutic efficacytherapeutic outcometherapeutic vaccinationtherapeutic vaccinetherapy efficacytherapy outcomethymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtreatment vaccinesunvaccinatedvaccine for the treatmentvaccine for treatmentviraemiaviral reboundviral sepsisvirus reboundvirusemiaαPD-1αPD1
Description preview
This proposal aims to develop an effective therapy to achieve HIV remission by improving the magnitude,
breadth, and function of anti-viral CD8 T cells and reducing viral reservoirs using the SIV/macaque model.
Dysfunctional anti-HIV immunity and the persistence of viral reservoirs represent two major issues that must be
addressed by therapeutic…
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