grant
Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and Aging
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 10 Sept 2013Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20253-Pyridinecarboxamide3-Pyridinecarboxylic AcidADP Ribose TransferasesADP-RibosyltransferaseADPRTsART TransferasesARTasesAgeAgingAmentiaAttentionAwardBBB penetrationBiochemical PathwayBiochemical ReactionBiological MarkersBiologyBloodBlood CirculationBlood Reticuloendothelial SystemBloodstreamBody TissuesCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeClinicalClinical ResearchClinical StudyConsumptionDataDeathDementiaDermatitisDiarrheaDihydronicotinamide Adenine DinucleotideDiphosphopyridine NucleotideDiseaseDisease OutcomeDisorderDistalDoseDrug KineticsElectron TransportElectronsEnzymatic ReactionEnzyme GeneEnzymesFormulationFutureGeneral PopulationGeneral PublicGenerationsGeneticGenetic ModelsGrantHealthHepatic CellsHepatic Parenchymal CellHepatocyteHeterozygoteHumanImpairmentInjuryIntermediary MetabolismInterphase CellIntestinalIntestinesIntracellular Communication and SignalingIsotope LabelingIsotopesKidneyKidney Urinary SystemKnock-outKnockoutL-TryptophanLearningLevotryptophanLiteratureLiverLiver CellsMapsMarketingMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMetabolicMetabolic NetworksMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaModelingModern ManMolecularMurineMusNADHNadideNatural regenerationNegative Beta ParticleNegatronsNiacinNiacinamideNicotinamideNicotinamide MononucleotideNicotinamide adenine dinucleotideNicotinamide-Adenine DinucleotideNicotinamidumNicotinic AcidsNicotinic acid amideNicotylamideNon-dividing CellNondividing CellNutraceuticalObesityOralOutcomeOxidation-ReductionPathogenesisPellagraPellagra-Preventing FactorPharmacokineticsPhenotypePhysiologicPhysiologicalPhysiologyProcessPublishingRadioisotope Dilution TechnicRadioisotope Dilution TechniqueReactionRedoxRegenerationResting CellRodent ModelRoleSignal TransductionSignal Transduction SystemsSignalingSilent Mating Type Information Regulator 2-like ProteinsSir2-like ProteinsSirtuinsSiteSkeletal MuscleSupplementationTechniquesTestingTherapeuticTherapeutic EffectTissuesTryptophanVitamin B 3Vitamin B3Vitamin PPVoluntary MuscleWorkadiposityaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging populationamidationbio-markersbiologic markerbiological signal transductionbiomarkerblood glucose regulationblood-brain barrier penetrationbloodbrain barrier penetrationbowelcofactorcorpulencedeamidationdietarydisease modeldisorder modelelectron energyelectron transferfallsglucose controlglucose homeostasisglucose metabolismglucose regulationhead-to-head analysishead-to-head comparisonhepatic body systemhepatic organ systemheterozygosityimprovedin vivoinjuriesinterestisotope dilution methodmitochondrialnatural agingnicotinamide ribonucleosidenicotinamide ribosenicotinamide ribosidenicotinamide-beta-ribosidenormal agingnormative agingobese individualsobese peopleobese personobese populationobese subjectsoverexpressoverexpressionoxidationoxidation reduction reactionpopulation agingpre-clinicalpre-clinical studypreclinicalpreclinical studyregeneraterenalribosidesocial roletherapeutically effectiveuptakewestern dietwestern-style dietwestern-type diet
Description preview
Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and Aging
We are testing the hypothesis that nicotinamide adenine dinucleotide (NAD+) metabolism can be targeted to
improve physiology in aged and obese individuals. NAD+ is a ubiquitous molecule that is required as a redox
cofactor or substrate for hundreds of enzymes within the…
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