grant
Targeting Lung Fibrosis Using Epigenetic Therapy
Organization UNIVERSITY OF KENTUCKYLocation LEXINGTON, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Adeno-Associated VirusesAlveolarAlveolar CellAttenuatedBasal Transcription FactorBasal transcription factor genesBeta Proprotein Interleukin 1BioavailabilityBiologic ModelsBiological AvailabilityBiological ModelsBleoBleomycinBody TissuesBone-Derived Transforming Growth FactorCAGH44Cell BodyCell Communication and SignalingCell Culture TechniquesCell LineageCell ReprogrammingCell SignalingCellsChIP SequencingChIP-seqChIPseqChromatinCicatrixCollagenComplexCristobaliteCytokine Signal TransductionCytokine SignalingDNA mutationDataDependoparvovirusDependovirusDevelopmentDiseaseDisease ProgressionDisorderDown-RegulationDrugsENX-1EZH1EZH2EZH2 geneEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumFDA approvedFOXP2FOXP2 geneFibroblastsFibrosisFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryForkhead Box P2Gene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationHarvestHistologicHistologicallyHistologyHistone H3HumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImmuneImmunesImmunoblottingInfectionInflammatoryInjuryInterleukin 1betaInterleukin-1 betaInterleukin-1βInterventionIntracellular Communication and SignalingKMT6KMT6AKnowledgeL-LysineLaboratoriesLifeLoxP-flanked alleleLungLung DiseasesLung Function TestsLung Respiratory SystemLung Tissue FibrosisLung damageLysineMedicationMedicineMesenchymalMethylationMiceMice MammalsMilk Growth FactorModel SystemModelingModern ManMurineMusMutationMyeloid CellsOralOrganoidsPatientsPersonsPharmaceutical PreparationsPhenotypePhysiologic AvailabilityPlatelet Transforming Growth FactorPolycombPopulationPreinterleukin 1 BetaPreventionPulmonary DiseasesPulmonary DisorderPulmonary FibrosisPulmonary function testsRNA ExpressionRNA SeqRNA sequencingRNAseqRadiationRepressionResearchRoleSamplingSandScarsSignal TransductionSignal Transduction SystemsSignalingSilicaSilicon DioxideStaining methodStainsSupporting CellSystemTGF BTGF-betaTGF-βTGFbetaTGFβTNRC10TestingTherapeuticTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTridymiteTrinucleotide Repeat-Containing Gene 10UpregulationViralWestern BlottingWestern Immunoblottingadeno associated virus groupallergic airway diseaseattenuateattenuatesbiological signal transductioncell culturecell culturescell typecellular reprogrammingchemotherapychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcytokinederepressiondevelopmentaldisease of the lungdisorder of the lungdrug/agentepigenetic therapyepigeneticallyfibrosis in the lungflow cytophotometryfloxedfloxed allelegenome mutationhistone H3 methyltransferasehistone methylasehistone methyltransferaseimprovedin vivoin vivo Modelinhibitorinjuriesinsightknock-downknockdownlung disorderlung fibrosislung functionlung injurylung repairlung tissue repairnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoverexpressoverexpressionpharmacologicpreventpreventingprofibrotic cytokineprogenitor biologyprogenitor cell biologypromoterpromotorprotein blottingpulmonary damagepulmonary functionpulmonary injurypulmonary repairpulmonary tissue damagepulmonary tissue injuryresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall moleculesocial rolestem and progenitor biologystem cell biologytranscription factortranscriptome sequencingtranscriptomic sequencing
Description preview
PROJECT SUMMARY
Pulmonary fibrosis is a complex disease that limits lung function through development of collagen-rich
scar tissue. Although there are currently two FDA-approved therapies for fibrosis patients, these drugs are
capable of extending life only months and do not reverse the progression of the disease. The research described
in this…
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