grant
Targeting LRP1 in Neuroinflammation and Neuropathic Pain
Organization VA SAN DIEGO HEALTHCARE SYSTEMLocation SAN DIEGO, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2028
VANIHUS FederalResearch GrantFY2025AccelerationAcuteAcute PainAcutely painfulAddressAffectAfferent NeuronsAgonistAmericanAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAnticonvulsant AgentAnticonvulsant DrugsAnticonvulsantsAnticonvulsive AgentsAnticonvulsive DrugsAnzataxApo E ReceptorApoE ReceptorApolipoprotein E ReceptorAsotaxAwardAxonBehaviorBindingBristaxolCOVID-19CV-19Cancer SurvivorCancer TreatmentCausalityCell BodyCell Communication and SignalingCell FunctionCell Migration AssayCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessChronicConduction-Blocking AnestheticsCoronavirus Infectious Disease 2019CutaneousDataDevelopmentDoseDrugsEtiologyEventFundingGP145-TRKCGene ExpressionGeneral PopulationGeneral PublicGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGliaGlial CellsGoalsHumanImmuneImmunesIncidenceInflammatoryInjuryIntracellular Communication and SignalingKolliker's reticulumLDL-Receptor Related Protein 1LaboratoriesLaboratory ResearchLeadLigandsLinkLocal AnestheticsLow Density Lipoprotein Receptor-Related ProteinLow-Density-Lipoprotein Receptor-Related Protein-1Malignant Neoplasm TherapyMalignant Neoplasm TreatmentMeasuresMediatorMedicationMetabolicMiceMice MammalsMigration AssayModalityModelingModern ManMolecularMolecular InteractionMurineMusNT3 Growth Factor ReceptorNTRK3 ProteinNTRK3 ReceptorNerveNerve CellsNerve FibersNerve Growth Factor 2Nerve UnitNervous System InjuriesNervous System PhysiologyNervous System TraumaNervous System damageNeural CellNeurilemma CellNeurilemmal CellNeurocyteNeurogliaNeuroglial CellsNeurologic functionNeurological DamageNeurological InjuryNeurological functionNeurological traumaNeuronsNeurotrophic Tyrosine Kinase Receptor Type 3Neurotrophin 3Neurotrophin 3 ReceptorNociceptionNon-neuronal cellNonneuronal cellOpiatesOpioidPNS DiseasesPaclitaxelPaclitaxel (Taxol)PainPain ControlPain TherapyPain managementPainfulParesthesiaPathogenesisPatientsPb elementPeptidesPeripheralPeripheral Nerve DiseasesPeripheral NervesPeripheral Nervous SystemPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPeripheral nerve injuryPharmaceutical PreparationsPhenotypePlayPraxelProcessPropertyProtein-Tyrosine Kinase TRKCProteinsProteomicsPublishingQOLQuality of lifeR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinRecombinant DNA TechnologyReportingResearchResearch DesignResearch GrantsResearch Project GrantsResearch ProjectsRoleSchwann CellsSensorySensory NeuronsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSite-Directed MutagenesisSite-Specific MutagenesisSteroid CompoundSteroidsStressStudy TypeSubcellular ProcessSymptomsSystemTRKC Tyrosine KinaseTargeted DNA ModificationTargeted ModificationTaxolTaxol ATaxol KonzentratTestingTherapeuticToxicant exposureTransactivationTransmissionTraumatic injuryVeteransWorkaddictionaddictive disorderafferent nervealpha-2-Macroglobulin Receptoralpha2-Macroglobulin Signaling Receptoranti-cancer therapyanti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsbiological signal transductioncancer therapycancer-directed therapycare resourcescausationchemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschemotherapychronic neuropathic painchronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19curative interventioncurative therapeuticcurative therapycurative treatmentsdebilitating paindesigndesigningdevelopmentaldisease causationdrug/agentearly experienceearly onsetgenetically engineeredhealth care resourcesheavy metal Pbheavy metal leadhippocampus derived neurotrophic factorimprovedimproved outcomeinflammatory paininjuredinjuriesinjury responseinnovateinnovationinnovativelab developmentlaboratory developmentmilitary servicemilitary veteranmouse modelmurine modelnerve cementnerve reconstructionnerve repairnervous system functionneural inflammationneuroinflammationneuroinflammatoryneuronalneuropathic painneurotraumanociceptivenon-narcotic analgesicnon-opiate analgesicnon-opioidnon-opioid analgesicnon-opioid therapeuticsnonnarcotic analgesicsnonopiate analgesicnonopioidnonopioid analgesicsnovelpain interventionpain outcomepain reductionpain treatmentpain-related outcomepainful neuropathypandemicpandemic diseaseperipheral nerve crush injuriespreventpreventingprogramsreceptorreceptor bindingreceptor boundreduce painrepairrepairedresearch visionresponseresponse to injuryscRNA sequencingscRNA-seqseizure drugseizure medicationsensory nerveservice programsside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestudy designtoxic exposuretrans-activationtranslational opportunitiestranslational potentialtransmission processtreat chronic paintrkC ProteintrkC Receptorveteran population
Description preview
It is increasingly apparent that Schwann cells (SCs) in the peripheral nervous system (PNS) function as a unit
with neurons to regulate sensory function. When the PNS is injured or stressed, SCs become activated for repair.
This involves dramatic SC phenotypic transformation. If this process is abnormal or inhibited, peripheral nerve
injury may…
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