grant
Targeting Hexosamine Synthesis in Pediatric Brain Tumors
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 15 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldATP-Methionine S-AdenosyltransferaseAberrant ChromosomeAddressAdemetionineAdoMetAdultAdult HumanAminotransferasesApoptosisApoptosis PathwayAssayBioassayBiologicalBiological AssayBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCancersCell BodyCellsCellular ExpansionCellular GrowthChildChild YouthChildhood Brain NeoplasmChildhood Brain TumorChildhood Malignant Brain TumorChildren (0-21)Chromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityClinicalClinical TrialsCodonCodon NucleotidesCytogenetic AberrationsCytogenetic AbnormalitiesD-GlucoseDNA mutationDataDependenceDevelopmentDextroseDifferential DisplayDiseaseDisorderEC 2.1.1EncephalonEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFoundationsFructoseGene TargetingGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomicsGlcN6P deaminaseGlcNAc transferaseGliaGlial Cell TumorsGlial CellsGlial NeoplasmGlial TumorGliomaGlnGlucosamine-6-phosphate isomeraseGlucoseGlutamineGlycolysisGrowthH3 K27M mutantH3 K27M mutationH3K27M mutantH3K27M mutationHexosaminesHistone H3HistonesImpairmentIn VitroIntermediary MetabolismKinasesKnowledgeKolliker's reticulumL-GlutamineL-LysineL-SerineL-ThreonineLeftLevuloseLinkLysineMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMessenger RNAMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMethionineMethionine MetabolismMethionine Metabolism PathwayMethylationMethyltransferaseMutationNagB proteinNeural Stem CellNeurogliaNeuroglial CellsNeuroglial NeoplasmNeuroglial TumorNon-neuronal cellNonneuronal cellO-linked N-acetylglucosamine transferaseO-linked UDP-N-acetylglucosaminyltransferase OGTPathway interactionsPatientsPediatric Malignant Brain TumorPhosphotransferase GenePhosphotransferasesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProgenitor CellsProgrammed Cell DeathPropertyProtein ModificationProteinsQ LevoglutamideQ. LevoglutamideRadiationReactionResistanceResistance developmentResistant developmentRoleS-AdenosylhomocysteineS-AdenosylmethionineS-Adenosylmethionine SynthetaseS-adenosyl methionineS-adenosyl-methionineSAMeSerineSomatic MutationSurvival RateTestingTherapeuticThreonineTissue GrowthTransaminasesTransphosphorylasesTumor BiologyUDP-GlcNAc-peptide-GlcNAc-transferaseUDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferaseWarburg Effectadulthoodaerobic glycolysisbiologiccell growthchildhood brain cancerchromosomal defectchromosome defectclinical relevanceclinically relevantdeveloping resistancedevelopmentaldifferential display techniquediffuse midline gliomaeffective therapyeffective treatmentempowermentepigeneticallyepigenomeepitranscriptomicsfructose-6-phosphategain of functiongenome mutationglial-derived tumorglucosamine-6-phosphate deaminaseglucosaminephosphate isomerasein vivoinhibitorkidsknock-downknockdownloss of functionmRNAmRNA Differential Displaysmalignancymethionine adenosyltransferasemethylaseneoplasm/cancernerve cementnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuroglia neoplasmneuroglia tumorneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornovelontogenypathwaypediatric brain cancerpediatric brain neoplasmpediatric brain tumorpre-clinicalpreclinicalpreventpreventingprogenitor and neural stem cellsprotein functionresistance mechanismresistantresistant mechanismresponsesocial rolesomatic variantstandard of carestem cellssynergismsystemic toxicitytransmethylasetumortumors in the brainyoungster
Description preview
PROJECT SUMMARY
Pediatric brain tumors display differential mutational profiles and tumor biology than adult tumors, suggesting
that pediatric brain tumor patients are not simply small adults. Diffuse midline gliomas (DMG) often harbor a
specific lysine-to-methionine mutation in Histone 3 (H3K27a), which portend a 5-year survival rate of only 2%.…
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