grant
Targeting dysfunctional epithelial repair in pulmonary fibrosis
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 15 Sept 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AGTR2AGTR2 geneAT2AcuteAcute Lung InjuryAcute Pulmonary InjuryAgreementAlveolarArchitectureAreaBleoBleomycinCell BodyCell Communication and SignalingCell SignalingCellsCo-cultureCocultivationCocultureCoculture TechniquesCollagenDataDepositDepositionDevelopmentDifferential Gene ExpressionDiseaseDisorderDoseEngineering / ArchitectureEpithelial CellsEpitheliumExpression SignatureFibroblastsFibrosing AlveolitisFibrosisFunctional RegenerationGasesGene Expression ProfileGene TranscriptionGenerationsGenetic TranscriptionGenomicsHIF 1HIF-1 proteinHIF1HIF1 proteinHumanHypoxia Inducible FactorImpairmentInjuryIntracellular Communication and SignalingLineage TracingLungLung Alveolar EpitheliaLung DiseasesLung ParenchymaLung Respiratory SystemLung TissueLung Tissue FibrosisMapsMediatorMetaplasiaMetaplastic ChangeMetaplastic Epithelial CellMiceMice MammalsModelingModern ManMurineMusOrganoidsPathway interactionsPhenotypePneumoniaPopulationProcessProfibrotic factorProfibrotic signalProgenitor CellsPulmonary DiseasesPulmonary DisorderPulmonary FibrosisRNA ExpressionRecoveryResolutionRoleSecretory CellSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructureStructure of parenchyma of lungTimeTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTranscriptionTransgenic MiceTransitional CellUpregulationWorkairway epithelial stem cellsairway progenitorairway stem cellsalveolar epitheliumbiological signal transductioncell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingdevelopmentaldiffuse interstitial pulmonary fibrosisdisease of the lungdisorder of the lungepithelial injuryepithelial repairfibrosis in the lunggene expression patterngene expression signaturehealinghypoxia inducible factor 1idiopathic pulmonary fibrosisimprovedimproved outcomeinhibitorinjurieslung disorderlung fibrosismouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypreventpreventingprogenitorrepairrepairedresolutionsrespiratory progenitorrespiratory stem cellrestorationscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem cellsstem cells in the airwaytherapeutic agent developmenttherapeutic developmenttranscriptional profiletranscriptional signaturetranscriptomics
Description preview
While it is generally agreed that epithelial injury is a central process in Idiopathic Pulmonary Fibrosis (IPF),
differential mechanisms that determine functional repair versus dysfunctional repair are incompletely
understood. Emerging data indicate that airway-derived progenitors can give rise to a variety of “transitional”
and proximal-like cell…
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