grant
Targeting cell fusion as a novel strategy to tackle JQ1 resistance in triple negative breast cancer
NIHUS FederalResearch GrantFY2025ABC15ABCG2ABCG2 geneABCPATP-Binding Cassette, Sub-Family G (WHITE), Member 2 GeneATP-Binding Cassette, Sub-Family G, Member 2ATP-Binding Cassette, Subfamily G, Member 2AcetylationAntibodiesApoptoticB7-H1BCRPBCRP1BindingBioinformaticsBlood monocyteBreast CancerBreast Cancer CellBreast Cancer Resistance ProteinBreast NeoplasmsBreast TumorsBromodomainCD14CD14 geneCD274CD44CD44 geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer GenesCancer TreatmentCancer-Promoting GeneCas nuclease technologyCell BodyCell ExtractsCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell fusionCellsChIP SequencingChIP-seqChIPseqChemoresistanceChromatinClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-cultureCocultivationCocultureCoculture TechniquesDNA Molecular BiologyDiseaseDisorderDown-RegulationDrug resistanceEST157481EpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFluorescenceFutureGene ExpressionGeneralized GrowthGenerationsGrowthHeterogeneityHistonesHumanHybrid CellsImmuneImmunesImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostIn VitroKnock-outKnockoutL-LysineLarge-Scale SequencingLysineMDA MB 231MDA-231MDA-MB231MDU3MRXMXR1Malignant Breast NeoplasmMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMammary CancerMammary NeoplasmsMammospheresMarrow monocyteMediatingMediatorMiceMice MammalsMitoxantrone Resistance ProteinModalityModelingModern ManMolecular BiologyMolecular InteractionMurineMusNamesNatureNon-Polyadenylated RNAOncogenesPD-L1PDL-1Pgp1Placenta-Specific ATP-Binding Cassette TransporterPopulationProcessProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1ProteinsQualifyingRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqReaderResistanceResistance developmentResistant developmentRibonucleic AcidSomatic Cell HybridsTNBCTailTechniquesTestingTherapeuticTissue GrowthTrainingTransforming GenesTumor CellUpregulationanti-cancer researchanti-cancer therapybreast tumor cellcancer cellcancer progenitorcancer progenitor cellscancer researchcancer stem cellcancer stem like cellcancer therapycancer-directed therapycell sortingchemoresistantchemotherapychemotherapy resistancechemotherapy resistantchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcollegecollegiatedesigndesigningdeveloping resistancedrug candidatedrug resistantenverinepigeneticallyexperienceimmunosuppressed patientin vivoinhibitorlentiviral-transducedlentivirally transducedlentivirus transducedmalignant breast tumormalignant progenitormalignant stem cellmammary tumormonocytemutantnamenamednamingneoplastic cellnew approachesnovelnovel approachesnovel strategiesnovel strategyoncogenic progenitoroncogenic stem cellsontogenyoverexpressoverexpressionpreventpreventingprogenitor cell markersprogenitor like cancer cellprogenitor markersprogenitor stem cell markersprogrammed cell death ligand 1programmed cell death protein ligand 1protein death-ligand 1receptor expressionresistance to Drugresistantresistant to Drugresponsestem cell biomarkersstem cell markersstem like cancer cellsyncytintargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptome sequencingtranscriptomic sequencingtriple-negative breast cancertriple-negative invasive breast carcinomatumorundergradundergraduateundergraduate student
Description preview
Triple negative breast cancer (TNBC) remains an aggressive disease due to the lack of targeted therapies and
low rate of response to chemotherapy that is currently the main treatment modality. Compared to other types of
breast cancer, TNBC tumor consists of more immune cells in tumor mass. Recently inhibitors of bromodomain
(BRD) proteins showed…
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