grant
Targeting breathing limitations to improve functional outcomes in HFpEF
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Aug 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAirAmericanBreathingBreathing MechanicsBreathlessnessCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemChestDiastolic heart failureDyspneaEpidemicExerciseExercise TestExertionForced Vital CapacityFrequenciesFunctional Residual CapacityGasesGoalsHF with preserved ejection fractionHFpEFHe elementHeart VascularHeliumHumanHyperpneaInvestigationMeasuresMechanicsModern ManNHLBINational Heart, Lung, and Blood InstituteNon obeseNonobeseO elementO2 elementObesityOxygenPatientsPatternPhasePhysiologyPopulationPrevalenceRecommendationRespiratory AspirationRespiratory InspirationRespiratory MechanicsRestRiskRoleSymptomsTestingTherapeuticThinkingThoraceThoracicThoraxTidal VolumeVital capacityWork of Breathingadiposityadulthoodcirculatory systemco-morbidco-morbiditycommon symptomcomorbiditycorpulencecostdebilitating symptomdensityexercise capacityexercise intolerancefunctional improvementheart failure with preserved ejection fractionheart failure with preserved systolic functionimprove functionimproved functional outcomesinspirationlung functionlung volumemechanicmechanicalmechanical loadneglectnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpreserved ejection fraction heart failurepulmonary functionrespiratory airway volumesocial rolethoughtsventilationwork groupworking group
Description preview
PROJECT SUMMARY/ABSTRACT
Dyspnea on exertion (DOE) and exercise intolerance are hallmark symptoms of heart failure with preserved
ejection fraction (HFpEF). The mechanisms of these symptoms are unknown, and no therapeutic strategy exists
for these debilitating symptoms. As such, NHLBI working groups recommend prioritizing studies that advance…
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