grant
Targeting anoctamin 6 to disrupt trogocytosis of cancer-associated fibroblasts
Organization RESEARCH INST OF FOX CHASE CAN CTRLocation PHILADELPHIA, UNITED STATESPosted 7 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026Blood PlasmaBlood VesselsCalciumCalcium Ion SignalingCalcium SignalingCancer BiologyCancersCell BodyCell Communication and SignalingCell Membrane LipidsCell ProtectionCell SignalingCell SurvivalCell ViabilityCell membraneCell-Mediated Lympholytic CellsCellsCholesterolCytolytic T-CellCytoplasmic MembraneCytoprotectionCytosolCytotoxic T CellCytotoxic T-LymphocytesEatingFibroblastsFood IntakeGatekeepingGeneralized GrowthGreekGrowthHumanImmuneImmune mediated therapyImmunesImmunityImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyIntercellular FluidInterstitial FluidsIntracellular Communication and SignalingKnowledgeLabelLipidsMalignant CellMalignant NeoplasmsMalignant TumorMembraneMembrane LipidsMiceMice MammalsMicroscopyModern ManMolecularMurineMusNutrientOutcomePDAC cancer cellPDAC cellPancreas AdenocarcinomaPancreas Ductal AdenocarcinomaPancreas NeoplasmsPancreas TumorPancreatic AdenocarcinomaPancreatic Ductal AdenocarcinomaPancreatic TumorPathway interactionsPatientsPhosphatidylserinesPlasmaPlasma MembranePlasma SerumPositionPositioning AttributeProcessProteinsResistanceReticuloendothelial System, Serum, PlasmaRoleSTIM1STIM1 geneSerine PhosphoglyceridesSignal TransductionSignal Transduction SystemsSignalingStromal Interaction Molecule 1StructureSynapsesSynapticT-CellsT-LymphocyteTestingTherapeuticTherapeutic InterventionTissue GrowthTumor CellTumor Immunityanti-canceranti-cancer immunotherapyanti-tumor immunityanticancer immunotherapyantitumor immunitybiological signal transductioncancer cellcancer immunitycancer immunotherapycancer microenvironmentcytoprotectivedensityexhaustionexperimentexperimental researchexperimental studyexperimentsfat metabolismfeedinggatekeeperimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenicityimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunotherapy for cancerimmunotherapy of cancerinhibitorintervention therapykiller T celllipid metabolismmalignancymembrane structureneoplasm/cancerneoplastic cellnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnonspecific phospholipid transfer proteinsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetontogenypancreatic cancer cellspancreatic ductal adenocarcinoma cellpancreatic neoplasiapancreatic neoplasmpancreatic tumor cellsparticlepathwayphospholipid scramblaseplasmalemmapreventpreventingresistantresponsesocial rolesynapsethymus derived lymphocytetumortumor microenvironmentuptakevascular
Description preview
Project Summary
The fibroblastic stroma comprises most of pancreatic adenocarcinoma mass and is remarkably devoid of
functional blood vessels. It has been assumed that the pancreatic cancer cells obtain their essential metabolites,
such as lipids, directly from the interstitial fluid, but we have found that this is not the case. Instead, we…
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