grant
Targeting Angiopoietin-like 4 (ANGPTL4) in Severe Community Acquired Pneumonia
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 4 Apr 2025Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026ANGPTL4ANGPTL4 geneAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAmericanAngiopoietin-Like 4BacteriaBacterial PneumoniaBiometricsBiometryBiostatisticsBlood PlasmaC-terminalCOVID associated pneumoniaCOVID crisisCOVID epidemicCOVID induced pneumoniaCOVID pandemicCOVID pneumoniaCOVID related pneumoniaCOVID-19COVID-19 associated pneumoniaCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 induced pneumoniaCOVID-19 infectionCOVID-19 pandemicCOVID-19 periodCOVID-19 pneumoniaCOVID-19 public health crisisCOVID-19 related pneumoniaCOVID-19 viral pneumoniaCOVID-19 virus infectionCOVID-19 yearsCOVID19 infectionCV-19CaringCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeChestCirculatory CollapseClinicalClinical ResearchClinical StudyClinical Treatment MoabClinical TrialsCoronavirus Infectious Disease 2019D pneumoniaeD. pneumoniaeDAG lipaseDataDeathDevelopmentDiacylglycerol LipaseDiglyceride LipaseDiplococcus pneumoniaeDysfunctionEnrollmentEpidemiologyFIAFFasting-Induced Adipose FactorFollow-Up StudiesFunctional disorderGeneticGenetic ModelsGenotypeGoalsGrippeHFARPHealth Care CostsHealth CostsHeparin-Clearing FactorHepatic Fibrinogen/Angiopoietin-Related ProteinHospital AdmissionHospital MortalityHospitalizationHourHuman GeneticsImmune responseIn-house MortalitiesInfectionInfluenzaInhospital MortalityIntracellular Communication and SignalingLinkLipemia-Clearing FactorLung InflammationMeasuresMechanical ventilationMediatorMendelian randomizationMetabolic DiseasesMetabolic DisorderMiceMice MammalsMolecularMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMonoclonal AntibodiesMorbidityMurineMusN-terminalNH2-terminalNHLBINational Heart, Lung, and Blood InstituteOrganOutcomePGARPPARG Angiopoietin-Related ProteinPathway interactionsPatient CarePatient Care DeliveryPatientsPeptidesPermeabilityPhysiopathologyPlasmaPlasma ProteinsPlasma SerumPneumococcusPneumologyPneumoniaPneumonitisPneumonologyPopulationPositionPositioning AttributePost-Heparin LipasePostheparin LipasePostheparin Lipoprotein LipasePre-Clinical ModelPreclinical ModelsPreclinical dataProcessProtein SecretionProteinsProteomicsPulmonary InflammationPulmonary MedicinePulmonologyQualifyingResearchResearch PriorityResolutionReticuloendothelial System, Serum, PlasmaRiskRoleS pneumoniaeS. pneumoniaeSARS-CoV-2 associated pneumoniaSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 induced pneumoniaSARS-CoV-2 infectionSARS-CoV-2 pandemicSARS-CoV-2 pneumoniaSARS-CoV-2 related pneumoniaSARS-CoV-2 viral pneumoniaSARS-CoV2 infectionSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSample SizeSamplingSepsisSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 pandemicSeveritiesSeverity of illnessShockSignal TransductionSignal Transduction SystemsSignalingSocietiesSourceStreptococcus pneumoniaeTestingTherapeuticThesaurismosisThoraceThoracicThoraxTranslational ResearchTranslational ScienceTriacylglycero-protein acylhydrolaseVariantVariationVascular PermeabilitiesVentilatorViralViral PneumoniaVirusacute careacute kidney injuryadverse consequenceadverse outcomeanti-microbialantimicrobialbacteria pathogenbacteria pneumoniabacterial communitybacterial pathogenbiobankbiological heterogeneitybiological signal transductionbiorepositorycare for patientscare of patientscaring for patientscirculatory shockclearing factor lipaseclinical heterogeneityclinical phenotypeclinical translationclinically translatablecohortcommunity acquired pneumoniacommunity associated pneumoniacoronavirus disease 2019coronavirus disease 2019 associated pneumoniacoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 induced pneumoniacoronavirus disease 2019 infectioncoronavirus disease 2019 pandemiccoronavirus disease 2019 pneumoniacoronavirus disease 2019 public health crisiscoronavirus disease 2019 related pneumoniacoronavirus disease associated pneumoniacoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease induced pneumoniacoronavirus disease pandemiccoronavirus disease pneumoniacoronavirus disease related pneumoniacoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 pneumoniacoronavirus infectious disease-19developmentaldisease severityenrollepidemiologicepidemiologicalepidemiological modelexperimentexperimental researchexperimental studyexperimentsflu infectionflu virus infectionfollow-up research studyfollow-up surveygenetic approachgenetic epidemiologic studygenetic epidemiologygenetic strategyhost responseimmune system responseimmunoresponseimprovedimproved outcomeinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2influenza infectioninfluenza virus infectioninsightlipoprotein lipasemAbsmechanical respiratory assistmechanically ventilatedmetabolism disordermolecular modelingmonoclonal Absmortalitymouse modelmultidisciplinarymurine modelpathogenpathogenic bacteriapathogenic viruspathophysiologypathwaypatient populationpatient responsepatient specific responsepneumonia due to COVIDpneumonia due to COVID-19pneumonia due to SARS-CoV-2pneumonia due to coronavirus diseasepneumonia due to coronavirus disease 2019pneumonia due to severe acute respiratory syndrome coronavirus 2pneumonia in COVIDpneumonia in COVID-19pneumonia in SARS-CoV-2pneumonia in coronavirus diseasepneumonia in coronavirus disease 2019pneumonia in severe acute respiratory syndrome coronavirus 2pneumonia modelpneumonia modelspre-clinicalpre-clinical studypreclinicalpreclinical findingspreclinical informationpreclinical studyprotein expressionpulmonaryresolutionsresponseresponsive patientsevere acute respiratory syndrome coronavirus 2 associated pneumoniasevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 induced pneumoniasevere acute respiratory syndrome coronavirus 2 pneumoniasevere acute respiratory syndrome coronavirus 2 related pneumoniashockssocial rolestudy with follow-uptranslation researchtranslational investigationtriacylglycerol protein acylhydrolaseviral pathogenvirus pathogen
Description preview
PROJECT SUMMARY
Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality in hospitalized patients
but therapeutics are limited. In response, identification of modifiable pathways to alter host response and
improve outcomes in patients with severe CAP has been highlighted as a NHLBI research priority. Our
research group has…
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