grant
Targeted Therapies for Glioma
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 19 Sept 2013Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20250-11 years oldATP-protein phosphotransferaseAddressAgreementAmino Acid SubstitutionAnabolismAwardB-raf-1BRAFBRAF geneBackBasic ResearchBasic ScienceBiological AgentBiological MarkersBiological ProductsBiometricsBiometryBiostatisticsBostonBrainBrain CancerBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancer CauseCancer CenterCancer EtiologyCancer GenesCancer-Promoting GeneCancersCell BodyCellsCessation of lifeChildChild YouthChildhoodChildren (0-21)Children's HospitalClinicalClinical ResearchClinical StudyClinical TrialsCombined Modality TherapyDF/HCCDNA Double Strand BreakDNA Repair PathwayDNA mutationDana-Farber Cancer InstituteData SetDeathDevelopmentDiseaseDisorderDorsumDrug TargetingDrugsEncephalonFood and Drug AdministrationFosteringFriendsFundingGEM modelGEMM modelGeneral HospitalsGenerationsGenetic ChangeGenetic defectGenetic mutationGenetically Engineered MouseGlial Cell TumorsGlial NeoplasmGlial TumorGliomaGoalsHospitalsHumanIntermediary MetabolismInvestigatorsKinase Family GeneLong-term Follow-upMR ImagingMR TomographyMRIMRIsMachine LearningMagnetic Resonance ImagingMalignant CellMalignant MelanomaMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMassachusettsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMedicineMelanomaMetabolicMetabolic ProcessesMetabolismMethodsModalityModelingModern ManMolecularMultimodal TherapyMultimodal TreatmentMutationNMR ImagingNMR TomographyNeuroglial NeoplasmNeuroglial TumorNuclear Magnetic Resonance ImagingOncogene ProductsOncogene ProteinsOncogenesOncogenicOncoproteinsOperative ProceduresOperative Surgical ProceduresParentsPathologyPathway interactionsPatientsPediatric HospitalsPersonsPharmaceutical PreparationsPhasePrognostic MarkerProgress ReportsProtein KinaseProteinsProtocolProtocols documentationPublishingPyrimidineR-Series Research ProjectsR01 MechanismR01 ProgramRAFB1RadiationRecommendationRecurrenceRecurrentRefractoryReproducibilityResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersResistanceScientistSubgroupSurgicalSurgical InterventionsSurgical ProcedureTeaching HospitalsTemodalTemodarTherapeuticTransforming GenesUSFDAUnited States Food and Drug AdministrationUnresectableVariantVariationVeinsWomanWorkZeugmatographyaddictionaddictive disorderadult youthantagonismantagonistbio-markersbiologic markerbiologicsbiomarkerbiopharmaceuticalbiosynthesisbiotherapeutic agentcancer cellcancer genomicscareerchemotherapyclinical imagingclinical materialclustered regularly interspaced short palindromic repeats screencohortcombination therapycombined modality treatmentcombined treatmentcomputer sciencedevelop therapydevelopmentaldiffuse midline gliomadrug developmentdrug/agentflexibilityflexiblegenetically engineered mouse modelgenetically engineered murine modelgenome mutationgenome scalegenome-widegenomewideglial-derived tumorglycogen synthase a kinasehydroxyalkyl protein kinaseimaging studyinhibitorintervention developmentkidslong-term followupmachine based learningmalignancymedical collegemedical schoolsmethazolastonemulti-modal therapymulti-modal treatmentmutantneoplasm/cancerneuroglia neoplasmneuroglia tumoroncogenomicsparentpathwaypatient responsepatient specific responsepediatricpediatric low grade gliomaphosphorylase b kinase kinasepoly ADP ribose glycohydrolase inhibitorpoly ADPR glycohydrolase inhibprognostic biomarkerprognostic indicatorprogramsrepairrepairedresistantresponseresponsive patientsatisfactionschool of medicineside effectstandard of carestructural biologysurgerysynthetic lethal interactionsynthetic lethalitytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttemozolomidetherapy developmenttooltreatment developmenttreatment strategytumortumors in the brainv-raf Murine Sarcoma Viral Oncogene Homolog B1young adultyoung adult ageyoung adulthoodyoungster
Description preview
Project summary
This is the renewal application of a SPORE initiative from Dana-Farber/Harvard Cancer Center. We
focus on gliomas of children and young adults. Our objective is to develop therapies targeted to
oncogenic drivers and/or oncogene-induced vulnerabilities of these tumors. Towards these ends, basic
scientists join with clinician…
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