grant
Targeted immune therapies in heart transplantation
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026AcuteAdoptedAlloantigenAllograftingAnti-Rejection TherapyAntibody-drug conjugatesAssayBioassayBiological AssayBody TissuesCancersCardiac DiseasesCardiac DisordersCardiac TransplantationChronicDataDrug DeliveryDrug Delivery SystemsDrug TargetingGenerationsGoalsHeart DiseasesHeart GraftingHeart TransplantationImmuneImmune TargetingImmune mediated therapyImmunesImmunologically Directed TherapyImmunosuppressive TherapyImmunotherapeutic agentImmunotherapyInfectionKineticsLifeMalignant NeoplasmsMalignant TumorMetabolic syndromeMethodsMiceMice MammalsModelingMurineMusNanotechnologyOrganPatientsPhenotypeResearchT-CellsT-LymphocyteTechniquesTherapeuticTherapeutic UsesTherapeutic immunosuppressionTimeTissuesToxic effectToxicitiesTransplant RecipientsTransplantationallograft rejectionartificial immunosuppressioncardiac allograftcardiac graftclinical applicabilityclinical applicationcollaborative approachdosagedraining lymph nodeexperimentexperimental researchexperimental studyexperimentsheart allograftheart disorderheart transplantimaging studyimmune drugsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic therapeuticsimmunosuppression therapyimmunotherapeuticsimmunotherapy agentimprovedimproved outcomeinnovateinnovationinnovativeinterestmalignancymouse modelmultidisciplinarymurine modelnano particlenano technano technologynano-sized particlenano-technologicalnanoparticlenanosized particlenanotechnanotechnologicalneoplasm/cancernovelpost-transplantpost-transplantationposttransplantposttransplantationpreventpreventingprogramsregional lymph nodesite targeted deliverytargeted deliverytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetraffickingtransplanttransplant modeltransplant patient
Description preview
Abstract
Heart transplantation has become the mainstay lifesaving therapeutic strategy for a growing number of patients
with irreversible, end-stage heart disease. However, numerous challenges must be met to improve long term
heart allograft rejection. Although immune therapeutics (ITs) used to prevent rejection have improved over time,
they are…
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