grant
Targeted Degradation of Extracellular Proteins to Enhance Brain Plasticity
Organization SALK INSTITUTE FOR BIOLOGICAL STUDIESLocation La Jolla, UNITED STATESPosted 12 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAbscissionAcuteAdultAdult HumanAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaApoplexyAreaAssayAstrocytesAstrocytusAstrogliaAtlasesBinding ProteinsBioassayBiological AssayBiotinBrainBrain Nervous SystemBrain Vascular AccidentCNS plasticityCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCoupledDegenerative Neurologic DisordersEncephalonEnvironmentEnzyme GeneEnzymesExcisionExtirpationExtracellular ProteinExtracellular SpaceGeneticGliaGlial CellsGoalsHealthInjuryIntercellular SpaceKolliker's reticulumLabelLeadLearningLigand Binding ProteinLigand Binding Protein GeneMemoryMetabolic Protein DegradationModelingNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNeuronal PlasticityNeuronsNeurosciencesNon-neuronal cellNonneuronal cellOutcomePb elementPrimary Senile Degenerative DementiaProtein BindingProtein BiosynthesisProtein SecretionProtein TurnoverProteinsReagentRegulatory Protein DegradationRemovalRepressionRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSourceStrokeSurgical RemovalSynapsesSynapticSynaptic plasticitySystemVHHVHH antibodyVisual SystemVitamin Hadulthoodastrocytic gliabound proteinbrain attackbrain cellbrain healthbrain repaircamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincandidate identificationcentral nervous system plasticitycerebral vascular accidentcerebrovascular accidentcoenzyme Rdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesfunctional improvementfunctional restorationheavy metal Pbheavy metal leadimprove functionimproved functional outcomesinjuriesinterestnanobodiesnanobodynerve cementneural plasticityneurodegenerative illnessneurological diseaseneuronalneuronal circuitneuronal circuitryneuroplasticneuroplasticitynew approachesnovel approachesnovel strategiesnovel strategyprimary degenerative dementiaprotein degradationprotein synthesisrepairrepairedresectionrestore functionrestore functionalityrestore lost functionsdAbsenile dementia of the Alzheimer typesingle domain antibodiessocial rolestrokedstrokessynapsetooluptakevariable heavy chain antibody
Description preview
PROJECT SUMMARY
The young brain displays remarkable plasticity. This includes an ability to remodel neuronal synaptic connections
to learn new tasks in health, as well as being able to repair connections and restore function after injury. In the
adult brain there are active mechanisms in place that maintain neuronal circuit connectivity and…
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