grant
Targetable pathways driving sub-optimal early-life CD8 T cell responses
NIHUS FederalResearch GrantFY2025(TNF)-α0-11 years old1-Phosphatidylinositol 3-Kinase21+ years old5 year old5 years of ageATAC sequencingATAC-seqATACseqAcuteAdultAdult HumanAssay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingAutopsyBiologyBlood SerumBronchiolitisCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCachectinCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCell Communication and SignalingCell DeathCell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCell SignalingCell-Mediated Lympholytic CellsCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChildChild YouthChildhoodChildren (0-21)ChromatinCritical CareCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesDataDeathDeath RateDevelopmentDiseaseDisorderDoctor of MedicineELISAEffector CellEnzyme-Linked Immunosorbent AssayExhibitsFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2Flow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFutureGene AlterationGene MutationGene TranscriptionGenetic TranscriptionGlycolysisGoalsHealthHospital AdmissionHospitalizationHumanHyperactivityImmuneImmune memoryImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologic MemoryImmunologicalImmunological MemoryImmunologicallyImmunologicsIn VitroInfantInfectionInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntermediary MetabolismInterventionIntracellular Communication and SignalingK-AwardsK-Series Research Career ProgramsKinasesLYT3LifeLungLung Respiratory SystemLymphocytopeniaLymphopeniaM.D.Macrophage-Derived TNFMeasuresMechanistic Target of RapamycinMediatingMemoryMentorsMetabolicMetabolic ProcessesMetabolismModelingModern ManMolecularMolecular TargetMonocyte-Derived TNFMorbidityMorbidity - disease rateNeonatalNeonatal MortalityOnset of illnessOut-patientsOutcomeOutpatientsPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePathogenicityPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypePhosphatidyl InositolPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphatidylinositolsPhosphoinositide 3-HydroxykinasePhosphoinositidesPhosphotransferase GenePhosphotransferasesPredispositionPrincipal InvestigatorProductionProliferatingPropertyPtdInsPtdIns 3-KinaseRAFT1RNA ExpressionRNA SeqRNA sequencingRNAseqRecoveryRegulationResearchResearch Career ProgramResearch MethodologyResearch MethodsResearch SpecimenRespiratory syncytial virusRoleSamplingSerumSeveritiesSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSpecimenSubcellular ProcessSusceptibilitySyndromeT cell responseT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT8 CellsT8 LymphocytesTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTherapeuticTranscriptionTranslational ResearchTranslational ScienceTransphosphorylasesTumor Necrosis FactorTumor Necrosis Factor-alphaType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseUniversitiesVaccinationViralViral BronchiolitisViral DiseasesVirusVirus DiseasesVisitWorkWorld Health Organizationadaptive immune responseadaptive immunityadult youthadulthoodage 5 yearsanamnestic reactionassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological signal transductioncareercellular differentiationcytotoxiccytotoxic CD8 T cellscytotoxic CD8 T lymphocytedeath among neonatesdeath among newbornsdeath in neonatesdeath in newborndevelopmentaldifferential expressiondifferentially expresseddisease onsetdisease severitydisorder onsetdrivingearly childhoodenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsfive year oldfive years of ageflow cytophotometrygene defecthost responsehypoimmunityimmune deficiencyimmune system responseimmunodeficiencyimmunopathologyimmunoresponseimprovedimproved outcomeinsightinterestkidskiller T celllife spanlifespanmTORmTOR InhibitormTOR Signaling Pathwaymammalian target of rapamycinmedical collegemedical schoolsmortalitymortality among neonatesmortality among newbornsmortality in neonatesmortality in newbornsmortality ratemortality ratiomutant allelenecrocytosisnecropsyneonatal deathneonatal demiseneonatal humanneonatal periodneonatenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynewborn deathnewborn mortalitynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoutcome following vaccinationoutcome following vaccinepathogenpathwaypatient oriented outcomespediatricpostmortempreventpreventingprofessorprogramsresearch and methodsresponseresult following vaccinationresult following vaccineschool of medicinesecondary immune responsesenescencesenescentskillssocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetranscriptional differencestranscriptome sequencingtranscriptomic sequencingtranslation researchtranslational investigationtranslational therapeuticstranslational therapyvaccination outcomevaccination resultvaccine outcomevaccine resultviral infectionvirus infectionvirus-induced diseaseyoung adultyoung adult ageyoung adulthoodyoungster
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PROJECT SUMMARY
Severe infection is one of the top three causes of neonatal mortality, according to the World Health Organization.
Of infection-related deaths, viruses cause 6.5% in neonates and 19.4% in infants. In children under five years of
age, infections with respiratory syncytial virus account for particularly high morbidity and mortality…
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