grant
T lymphocyte-mediated protection of the reproductive mucosa
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 10 Apr 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2025AccelerationAdoptionAntibodiesAntigensAssayAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBioassayBiogenesisBiological AssayBiologyBody TissuesBone-Derived Transforming Growth FactorCD51 AntigensCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCell BodyCell Communication and SignalingCell SignalingCellsCo-cultureCocultivationCocultureCoculture TechniquesControlled EnvironmentDefense MechanismsDevelopmentEffector CellEnvironmentEpitheliumEsteroproteasesExposure toFutureGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGeneticGenetic TranscriptionGerm-FreeGoalsHeterogeneityHumanIFNImmuneImmune SurveillanceImmunesImmunityImmunologic SurveillanceImmunosurveillanceIn VitroInfectionInflammationIntegrin alphaVIntegrin αVIntegrinsIntegrins Extracellular MatrixInterferonsIntracellular Communication and SignalingInvadedKnowledgeLYT3Laboratory AnimalsMaintenanceMediatingMemoryMethodsMiceMice MammalsMilk Growth FactorModelingModern ManMolecularMucosaMucosal TissueMucous MembraneMurineMusNatureOrganOrganoidsOrigin of LifeParabiosisPathogenicityPathway interactionsPeptidasesPeptide HydrolasesPhenotypePlatelet Transforming Growth FactorPopulationPositionPositioning AttributeProcessProductionPropertyProtease GeneProteasesProteinasesProteolytic EnzymesRNA ExpressionRegulationReporterRoleShapesSignal TransductionSignal Transduction SystemsSignalingSiteSourceSupporting CellSystemT cell differentiationT-CellsT-LymphocyteT-bet proteinT-bet transcription factorT8 CellsT8 LymphocytesTGF BTGF-betaTGF-βTGFbetaTGFβTestingTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneUpregulationVaccinationVaccinesVaginaViralViral DiseasesVirusVirus DiseasesWomen's studyWorkalpha(V) Integrinartificial environmentbiological signal transductioncell typecervicovaginalcytokinedensitydevelopmentaldrivingdysbacteriosisdysbiosisdysbioticfemale genital tractfemale reproductive tractfemale studyimmunogenimprovedin vivoinflammatory environmentinflammatory milieuinsightmicrobialmicrobial imbalancemicrobiomemouse modelmurine modelneutralizing antibodynew approachesnon-human primatenonhuman primatenovelnovel approachesnovel strategiesnovel strategypathogenpathogenic viruspathwaypsychological defense mechanismrecruitreproductivescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestudy among femalesstudy among womenstudy in femalesstudy in womenstudy on femalesstudy on womenstudy within womentargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetraittranscription factorviral infectionviral pathogenvirus infectionvirus pathogenvirus-induced diseasewomen's genital tractwomen's reproductive tract
Description preview
PROJECT SUMMARY
The female reproductive tract (FRT) mucosa is routinely invaded by pathogenic viruses. Resident memory CD8
T cells (TRM) have proven antiviral roles in this barrier tissue. Recent studies in mice and non-human primates
have demonstrated that when present in sufficient numbers, TRM can mediate rapid antiviral protection.
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