grant
T lymphocyte bystander responses in male-biased myocarditis
NIHUS FederalResearch GrantFY2025Androgen ReceptorAndrogenic AgentsAndrogenic CompoundsAndrogensAntigensAutoimmune StatusAutoimmunityAutomobile DrivingBioinformaticsBiopsyBloodBlood Reticuloendothelial SystemBlood SerumBody TissuesC-C CKR-5C-C CKR-5 GeneC-C Chemokine Receptor Type 5C-C Chemokine Receptor Type 5 GeneCC Chemokine Receptor 5CC-CKR-5CC-CKR-5 GeneCC-CKR5CCCKR5CCCKR5 GeneCCR-5CCR-5 GeneCCR5CCR5 ProteinCCR5 ReceptorsCCR5 geneCD183CD195 AntigenCD195 Antigen GeneCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCHEMR13CHEMR13 GeneCKR-5CKR-5 GeneCKR-L2CKR5CKR5 GeneCKR5 ReceptorsCMKAR3CMKBR5CMKBR5 GeneCXCR3CXCR3 geneCardiacCareer MobilityCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-Mediated Lympholytic CellsCell-to-Cell InteractionCellsChemokine (C-C Motif) Receptor 5Chemokine (C-C) Receptor 5Chemokine (C-C) Receptor 5 GeneChemokine (C-X-C Motif) Receptor 3Chemokine Receptor GeneComputer softwareCoupledCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesDataData AnalysesData AnalysisDiseaseDisease ManagementDisorderDisorder ManagementDisproportionate number of menDisproportionately impacts malesDisproportionately in menDrugsEndothelial CellsEndotheliumEnvironmentFemaleG Protein-Coupled Receptor 9GPR9Gender BiasHIV-1 Fusion Co-ReceptorHIV-1 Fusion Co-Receptor GeneHeartHeart failureHumanIL-15IL15IL15 ProteinIP10IP10 ReceptorIP10-Mig receptorIP10-RImageImmuneImmune infiltratesImmune memoryImmune responseImmunesImmunofluorescenceImmunofluorescence ImmunologicImmunologic MemoryImmunological MemoryImmunologyIndividualInfectionInfiltrationInflammationInflammatoryInjectionsInterleukin-15Interleukin-15 PrecursorIntracellular Communication and SignalingIntravenousLearningMGC9721MediatingMedicationMiceMice MammalsMig ReceptorMig-RMigRModelingModern ManMurineMusMyocardial depressionMyocardial dysfunctionMyocarditisMyocardiumPathologyPatientsPeripheralPharmaceutical PreparationsPhysiciansPlayPopulationPredispositionProcessPublishingRNA immunizationRNA vaccinationRNA vaccineRNA-based vaccineResearchRoleScientistSerumSex BiasSignal TransductionSignal Transduction SystemsSignalingSiteSoftwareSpecificityStimulusSudden DeathSupplementationSusceptibilitySystemT cell infiltrationT cell responseT memory cellT-Cell ActivationT-Cell DepletionT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT-cell depletion therapyT-lymphocyte depletion therapyT8 CellsT8 LymphocytesTechnical ExpertiseTechniquesTechnologyTestingTherapeutic AndrogenTissuesToxinTrainingTranslational ResearchTranslational ScienceTroponinVaccinatedVaccinationVaccinesViral DiseasesVirus DiseasesWorkactivate T cellsanamnestic reactionautoinflammationbiological signal transductioncardiac damagecardiac dysfunctioncardiac failurecardiac inflammationcardiac musclecareer advancementcareer transitionchemokine receptorclinical careclinical relevanceclinically relevantcomparing females and malescomparing women and mencytokinedata interpretationdeprivationdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedisproportionately affects malesdisproportionately affects mendisproportionately concentrated among mendisproportionately distributed among mendisproportionately higher among mendisproportionately impacts mendisproportionately occurs in mendrivingdrug/agentfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesgerm free conditionheart damageheart dysfunctionheart musclehistopathologic examinationhistopathological examinationhost responseimagingimaging approachimaging based approachimmune cell infiltrateimmune system responseimmunogenimmunoresponseimprovedin vivoin vivo Modelinsightkiller T cellmRNA immunizationmRNA vaccinationmRNA vaccinemRNA-based vaccinemalemale biasmale predominancememory T lymphocytemen disproportionately diagnosedmen disproportionately experiencemen experience disproportionate ratesmicrobialmulti-modalitymultimodalitynovelpredominantly affecting menresponsesecondary immune responsesexskillssocial rolespecific pathogen freetechnical skillsthymus derived lymphocytetranslation researchtranslational investigationvaccine developmentviral infectionviral myocarditisvirally-induced myocarditisvirus infectionvirus-induced diseasevirus-induced myocarditiswomen compared to menwomen compared with menwomen versus menwomen vs. men♀♂
Description preview
Project Summary/Abstract
Myocarditis, which is inflammation of the heart muscle mediated by immune cell infiltration and tissue damage,
can lead to cardiac dysfunction or sudden death. The most common cause of myocarditis is viral infection,
followed by other triggers including mRNA vaccination. Myocarditis, including after viral infection and…
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