grant
T cells promoting transitions toward autoimmunity
Organization BENAROYA RESEARCH INST AT VIRGINIA MASONLocation SEATTLE, UNITED STATESPosted 18 Aug 2023Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2024AddressAssayAutoantigensAutoimmuneAutoimmune DiseasesAutoimmune MechanismAutoimmune ProcessAutoimmune StatusAutoimmunityAutologous AntigensBioassayBiological AssayBiological MarkersBrittle Diabetes MellitusCell BodyCell CompartmentationCell CompartmentationsCellsChromatinClinicalCollaborationsCollectionDataDiagnosisDiseaseDisorderDown's SyndromeEffector CellEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFailureFingersFundingGene variantGenesGeneticGenetic DiseasesGenetic RiskGoalsHealth HazardsHomeIDDMImmuneImmune ToleranceImmunesImmunochemical ImmunologicImmunologicImmunologic ToleranceImmunologicalImmunologicallyImmunologicsIn VitroIndividualInsulin-Dependent Diabetes MellitusJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLangdon Down syndromeLeadershipLong-term cohortLongitudinal StudiesLongitudinal cohortLongterm cohortMemoryMongolismNatural HistoryNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesPathogenicityPathway interactionsPopulationProcessProspective cohortPublishingRegulatory RegionsResearch DesignRiskRisk-associated variantRoleSamplingSelf-AntigensStagingStudy TypeSudden-Onset Diabetes MellitusSurfaceT memory cellT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMTeff cellTestingTrisomy 21Type 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVariantVariationWorkallele variantallelic variantautoimmune conditionautoimmune disorderautoimmune inflammationautoimmune reactivityautoimmunity diseaseautoreactivitybio-markersbiobankbiologic markerbiomarkerbiorepositorycell typechromosome 21 trisomy syndromecohortcongenital acromicria syndromecostdisease riskdisorder riskeffector T cellenvironmental riskepigeneticallygenetic conditiongenetic disordergenetic regulatory elementgenetic variantgenomic variantglobal gene expressionglobal transcription profilehigh riskhomesimmune system toleranceimmune unresponsivenessimmunological paralysisin vitro Assayin vivoindividual patientinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabeteslong-term studylongitudinal outcome studieslongterm studymemory T lymphocytemorbus Downmulti-modalitymultimodalitynovelpathwaypre-clinicalpreclinicalprecursor cellpreventpreventingprogression riskprospectivepseudohypertrophic progressive muscular dystrophyresponse to therapyresponse to treatmentrestraintrisk allelerisk generisk genotyperisk locirisk locusrisk variantsample collectionsocial rolespecimen collectionstudy designtherapeutic responsetherapy responsethymus derived lymphocytetranscriptometreatment responsetreatment responsivenesstrisomy 21 syndrometype I diabetestype one diabetes
Description preview
SUMMARY
Autoimmune disease results from a combination of immunologic missteps involving multiple genes, cell types
and environmental factors. In the proposed studies, we will study how these factors promote the transition from
sub-clinical autoimmunity to autoimmune disease by comparing individuals at risk for type 1 diabetes, a disease
with a…
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