grant
T Cell Memory to Viruses
NIHUS FederalResearch GrantFY2025AddressAntigen-Presenting CellsAntigensAutoimmune StatusAutoimmunityBody TissuesBone-Derived Transforming Growth FactorCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChronicClinicCollaborationsCombination immunotherapyCombined Modality TherapyDysfunctionEffector CellFunctional disorderGoalsHealthHumanIL-7IL-7 GeneIL7IL7 ProteinIL7 geneImmune mediated therapyImmunologically Directed TherapyImmunotherapyInfectionInterleukin 7 PrecursorInterleukin 7 Precursor GeneInterleukin-7Interleukin-7 GeneIntracellular Communication and SignalingLCM VirusesLCMVLettersLife StyleLifestyleLong-term infectionLymphatic TissueLymphocytic choriomeningitis virusLymphoidLymphoid TissueLymphopoietin-1Malignant NeoplasmsMalignant TumorMiceMice MammalsMilk Growth FactorModern ManMultimodal TherapyMultimodal TreatmentMurineMusNIAIDNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthOutputPD 1PD-1PD1Pathway interactionsPhysiopathologyPlatelet Transforming Growth FactorPlayPopulationProgenitor CellsProliferatingReceptor ProteinResearch ProposalsResearch ResourcesResourcesRoleScientistSeaSignal TransductionSignal Transduction SystemsSignalingSiteStem Cell likeSubcellular ProcessT cell responseT memory cellT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT8 CellsT8 LymphocytesTGF BTGF-betaTGF-βTGFbetaTGFβTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneUnited States National Institutes of HealthViral BurdenViral CancerViral DiseasesViral LoadViral Load resultVirusVirus DiseasesWorkaccessory cellbiological signal transductionchronic infectioncombination therapycombinatorial immunotherapycombined modality treatmentcombined treatmentdual immunotherapyexhaustimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimprovedinsightmalignancymemory T lymphocytemulti-modal therapymulti-modal treatmentneoplasm/cancernon-human primatenonhuman primatenovelpathophysiologypathwaypersistent infectionprogenitor capacityprogenitor cell differentiationprogenitor cell likeprogenitor differentiationprogenitor-likeprogrammed cell death 1programmed cell death protein 1programmed death 1receptorselective expressionselectively expressedself-renewself-renewalsle2social rolestem and progenitor differentiationstem cell characteristicsstem cell differentiationstem cellsstem-likestemnesssystemic lupus erythematosus susceptibility 2thymus derived lymphocyteviral infectionvirus infectionvirus-induced disease
Description preview
Chronic viral infections are characterized by a state of T cell dysfunction that is associated with expression of
the PD-1 (programmed cell death 1) inhibitory receptor. A better understanding of the mechanisms that regulate
CD8 T cell responses during chronic viral infection is required to improve immunotherapies that will increase T
cell…
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