grant
T cell Development and Regeneration
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Basal Transcription FactorBasal transcription factor genesBlood Plasma CellBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCell BodyCell Communication and SignalingCell LineageCell SignalingCellsDefectDevelopmentDrug TargetingEpithelial CellsGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic ModelsGenetic TranscriptionGrowthHematopoieticImmuneImmunesIntracellular Communication and SignalingLaboratoriesLymphatic cellLymphocyteLymphocyticLymphoid CellMaintenanceModelingMolecularMultiple MyelomaNatural regenerationOrganOsteoblastsPlasma CellsPlasma-Cell MyelomaPlasmacytesPurine ReceptorsPurinergic ReceptorsPurinoceptorRNA ExpressionRegenerationRoleSignal TransductionSignal Transduction SystemsSignalingSystemT cell responseT-Cell DevelopmentT-Cell OntogenyT-CellsT-LymphocyteT-Lymphocyte DevelopmentThymic epithelial cellThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissue GrowthTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesWorkage associatedage correlatedage dependentage linkedage relatedage reversalage specificaging reversalalleviate age relatedalleviate agingameliorating aginganalyze gene expressionbiological signal transductioncell typecounter age relatedcounter agingcounteract age relatedcounteract agingdevelopmentalgene expression analysisgene expression assayhemopoieticinsightinterestlymph celllymphocyte precursorlymphocyte progenitorlymphocyte stem celllymphoid precursorlymphoid progenitorslymphoid stem cellmyelomamyelomatosisnotchnotch proteinnotch receptorsontogenyplasmocyteprogenitorprogramsregeneratereverse agereverse agingreverse aging effectsreversible agingsocial rolethymic regenerationthymus derived lymphocytethymus regenerationtranscription factortranscriptional profiling
Description preview
We have identified the earliest known precursors committed to innate cell lineages, and are characterizing the functions of transcription factors expressed in these early innate lymphocyte precursors. We devised a genetic model to study the activity of progenitors for thymus epithelial cells, and are currently characterizing the activity of these…
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