grant
T cell Contributions to Neointima Formation in Pulmonary Hypertension
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AblationAbnormal CellAccelerationAdaptive Immune SystemAdoptive TransferAgonistAntibodiesAntigensAutoimmune DiseasesAutomobile DrivingBase SequenceBasic ResearchBasic ScienceBiologyBiomedical EngineeringBlood VesselsBlood flowBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCardiac MalformationCell BodyCell Communication and SignalingCell LineageCell ShapeCell SignalingCellsCellular biologyCessation of lifeChronicClonal ExpansionClone CellsCo-cultureCocultivationCocultureCoculture TechniquesCommunicable DiseasesComplexComplicationDataDeathDevelopmentDiseaseDisorderDoctor of PhilosophyEndotheliumFOXP3FOXP3 geneForkhead Box P3FutureGeneralized GrowthGeneticGoalsGrowthHeart MalformationHouse Dust MitesHousedust MitesHumanImmuneImmune Modulation TherapyImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIn VitroInfectious DiseasesInfectious DisorderInflammationInterstitial Lung DiseasesIntracellular Communication and SignalingInvoluntary MuscleJM2LaboratoriesLesionLigandsLungLung DiseasesLung GraftingLung InflammationLung ParenchymaLung Respiratory SystemLung TissueLung TransplantationLymphoid FollicleLymphotoxinLymphotoxin ALymphotoxin-alphaLymphotoxin-αMHC ReceptorMacrophageMajor Histocompatibility Complex ReceptorMapsMeasuresMediatingMember 1 TNF SuperfamilyMentorsMesenchymalMiceMice MammalsModelingModern ManMolecular FingerprintingMolecular ProfilingMurineMusMyelogenousMyeloidMφNon-Polyadenylated RNANucleotide SequenceOrganOutcomePathogenicityPathologyPatientsPh.D.PhDPneumonitisPositionPositioning AttributeProcessPulmonary ArteryPulmonary DiseasesPulmonary DisorderPulmonary GraftPulmonary HypertensionPulmonary InflammationPulmonary TransplantPulmonary TransplantationPulmonary artery structurePyroglyphidaeRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqReceptor ProteinRecoveryRegulatory T-LymphocyteResearch InfrastructureResistanceRibonucleic AcidRoleSCURFINShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmooth MuscleSplenocyteStructure of parenchyma of lungSystemT cell receptor repertoire sequencingT cell receptor sequencingT cell reconstitutionT-Cell Antigen ReceptorsT-Cell ProliferationT-Cell ReceptorT-CellsT-LymphocyteT-cell receptor repertoireT4 CellsT4 LymphocytesTCR repertoireTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTNF-bTNF-betaTNF-βTNFSF1TNFβTechniquesTechnologyTestingTherapeutically TargetableTissue GrowthTissuesTrainingTranslational ResearchTranslational ScienceTregTumor Necrosis Factor-BetaTumor Necrosis Factor-βUniversitiesabnormal heart developmentacquired immune systemadjudicationadjudicative process and procedureautoimmune conditionautoimmune disorderautoimmunity diseasebio-engineeredbio-engineersbiobankbioengineeringbiological engineeringbiological signal transductionbiorepositorycareercell biologycell typecongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationcurative interventioncurative therapeuticcurative therapycurative treatmentsdevelopmentaldisease of the lungdisorder of the lungdrivingexperiencehost responsehuman diseasehuman tissueimmune modulatory therapiesimmune modulatory treatmentimmune reconstitutionimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune system responseimmune-modulation treatmentimmunogenimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseimpaired pulmonary vascularizationimprovedinsightlung disorderlung transplantlung vascular diseaselung vascular inflammationmolecular phenotypemolecular profilemolecular signaturemouse geneticsmouse modelmurine modelneointima formationneointimal thickeningnucleic acid sequenceontogenypersonalized immunotherapypre-clinicalpre-clinical studyprecision immunotherapypreclinicalpreclinical studypulmonarypulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vascular inflammationpulmonary vasculopathyreceptorregulatory T-cellsresistantresponseright heart failureright sided heart failureright ventricle failureright ventricular failureright ventricular heart failurescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporaltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic immunomodulationtherapeutic immunoregulationthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtranslation researchtranslational investigationvascularvascular inflammation
Description preview
Pulmonary Hypertension (PH) is a fatal disease where abnormal cells termed “neointima” progressively
occlude the pulmonary arteries leading to debilitating right heart failure. PH pathology is characterized by
perivascular inflammation, including T cell rich Tertiary Lymphoid Follicles (TLFs). Although perivascular
inflammation associates with…
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