grant
Systems genetics analysis of tumor evolution in the mouse
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jun 2017Deadline 31 Jul 2032
NIHUS FederalResearch GrantFY2025BenignBiologic ModelsBiological ModelsBody TissuesCXCL12CXCL12 geneCXCL12 proteinCXCR4 Signaling PathwayCancer GenesCancer Susceptibility GeneCancer-Predisposing GeneCancer-Promoting GeneCancersCell BodyCell CycleCell Division CycleCellsCellular injuryChemicalsChemokine (C-X-C Motif) Ligand 12ChronicCritical PathsCritical PathwaysDNADNA DamageDNA InjuryDNA mutationDataDeoxyribonucleic AcidDevelopmentDiseaseDisorderDrug usageDrugsEnvironmentEnvironmental genotoxicantEquilibriumEvolutionExposure toFaceGene ExpressionGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenotoxinsGoalsHair FollicleHair follicle structureHumanInflammationIsoformsLineage TracingLinkMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMedicationMethodsMiceMice MammalsMinorModel SystemModelingModern ManMurineMusMutagensMutateMutationNeoplasmsNetwork AnalysisOncogenesOutcomePBSFPathway AnalysisPharmaceutical PreparationsPlayPre-B Cell Growth Stimulating FactorPreventionProgenitor CellsProliferatingProtein IsoformsPublishingRNA SplicingResearchRoleRouteSCYB12SDF-1SDF-1ASDF-1BSDF-1alphaSDF1SDF1ASDF1BSdf1 proteinSkinSplicingStromal Cell-Derived Factor 1SystemTLSF-ATLSF-BTPAR1TissuesTransforming GenesTumor PromotersVariantVariationWorkWound Repairbalancebalance functioncancer progenitorcancer progenitor cellscancer stem cellcancer stem like cellcarcinogenicitycell damagecell injurycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular damagecellular lineage mappingcellular lineage trackingdamage to cellsdevelopmentaldrug usedrug/agentenvironmental mutagenesisenvironmental mutagensfacesfacialgenetic analysisgenetic approachgenetic strategygenome mutationgenotoxic agenthIRHhuman tissueindividual patientinjury to cellsmalignancymalignant progenitormalignant stem cellmouse modelmurine modelneoplasianeoplasm/cancerneoplastic growthnoveloncogenic progenitoroncogenic stem cellsprogenitor cell fateprogenitor cell markersprogenitor fateprogenitor like cancer cellprogenitor markersprogenitor stem cell markersprogramsresponsescRNA sequencingscRNA-seqself-renewself-renewalsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem and progenitor cell fatestem cell biomarkersstem cell fatestem cell markersstem cellsstem like cancer cellstromal cell-derived factor-1alphatumortumor growthtumor initiationwound healingwound recoverywound resolution
Description preview
Abstract
The major goal of our research has been to develop a comprehensive mouse model system for studying
cancer evolution from the cell of origin, through early pre-neoplasia, to malignant and widely disseminated
disease. We also wished to encompass the critical roles played by environmental mutagens, tumor promoters,
and variable host genetic…
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