grant
Systematic Testing of a TGFβ Targeted Theranostic in Preclinical Cancer
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 16 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20264T190YAddressAffectAmino AcidsAnti-CD20 AntibodyAntibodiesBindingBiologic Relative EffectivenessBiologicalBiologyBody TissuesBone-Derived Transforming Growth FactorBrain CancerBrain MetastasisBreastBreast CancerCancer BiologyCancer ModelCancer TreatmentCancerModelCancersCartoonsCell Communication and SignalingCell SignalingClinicalCollaborationsCompetenceDNA Damage RepairDNA RepairDataDefinitive Radiation TherapyDetectionDigestive Tract TumorDigestive TumorDoseDose RateDrug KineticsDrugsEBRTEngineeringExternal Beam RTExternal Beam Radiation TherapyExternal RadiationFOLHFOLH1FOLH1 geneFolate Hydrolase 1GCP2GI NeoplasmGI Tract TumorGI TumorGastrointestinal NeoplasmsGastrointestinal Tract TumorGastrointestinal TumorGerminoblastic SarcomaGerminoblastomaGlioblastomaGlutamate Carboxypeptidase IIGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHeterogeneityHeterograftHeterologous TransplantationHu-mABsHumanImageImmuneImmune responseImmunesImmunityImmunocompetentIntracellular Communication and SignalingIobenguaneIsotopesKnowledgeLabelLiteratureLungLung Respiratory SystemLymphomaMIBGMalignant Breast NeoplasmMalignant LymphomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Soft Tissue NeoplasmMalignant Thyroid Gland NeoplasmMalignant TumorMalignant Tumor of the BrainMalignant Tumor of the LungMalignant Tumor of the ThyroidMalignant Tumor of the Thyroid GlandMalignant neoplasm of brainMalignant neoplasm of lungMalignant neoplasm of prostateMalignant neoplasm of thyroidMalignant prostatic tumorMeasuresMedical ImagingMedicationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the BrainMetastatic TumorMetastatic Tumor to the BrainMetastatic malignant neoplasm to brainMiceMice MammalsMilk Growth FactorModelingModern ManMolecular InteractionMurineMusN-Acetylated Alpha-Linked Acidic Dipeptidase 1NAALAD1NAALADase INeoplasm MetastasisNeoplasm of the Digestive TractNeoplasm of the GI TractNeoplasm of the Gastrointestinal TractNeuroblastomaNeuroendocrineNeuroendocrine NeoplasmNeuroendocrine SystemNeuroendocrine TumorsNeurosecretory SystemsNormal TissueNormal tissue morphologyPETPET ScanPET imagingPETSCANPETTPSMPSMAPatient SelectionPatientsPeptidesPharmaceutical PreparationsPharmacokineticsPhysiologicPhysiologicalPlatelet Transforming Growth FactorPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary NeoplasmPrimary TumorPrincipal InvestigatorProcessProstate CAProstate CancerProstate malignancyProstate-Specific Membrane AntigenProteinsPulmonary CancerPulmonary malignant NeoplasmRad.-PETRadiationRadiation BiologyRadiation SensitivityRadiation ToleranceRadioactive IsotopesRadiobiologyRadioisotopesRadiolabeledRadionuclidesRadiopharmaceutical CompoundRadiopharmaceuticalsRadiosensitivityRelative Biological EffectivenessReticulolymphosarcomaSPECTSPECT imagingSarcomaSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSingle-Photon Emission-Computed Radionuclide TomographyTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticThyroidThyroid CancerThyroid GlandThyroid Head and NeckTimeTissue imagingTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTranslatingTreatment EfficacyTumor BiologyTumor VolumeUnscheduled DNA SynthesisWorkXenograftXenograft procedureXenotransplantationY-90Yttrium 90absorptionaminoacidanti-CD20anti-cancer therapybiologicbiological signal transductionbrain micrometastasiscancer metastasiscancer microenvironmentcancer therapycancer typecancer-directed therapyclinical validationdigestive neoplasmdosimetrydrug/agentexternal-beam radiationextracellularglioblastoma multiformehost responsehumAbshuman mAbshuman monoclonal antibodieshuman monoclonalsimagingimmune competentimmune system responseimmunoresponsein vivoinnovateinnovationinnovativeintervention efficacyirradiation responselung cancerm-Iodobenzylguanidinemalignancymalignant breast tumormalignant soft tissue tumormeta-Iodobenzylguanidinemetaiodobenzylguanidinemouse modelmurine modelneoplasm/cancerneuroendocrine cancerneuroendocrine malignancyneutralizing antibodyoverexpressoverexpressionpatient populationpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpreclinicalradiation responseradio-sensitivityradioactive drugsradiolabelradiolabelingradiolabelsradiologically labeledradiosensitiveradiotherapeutic drugsradiotracerresponseresponse to radiationresponse to therapyresponse to treatmentsingle photon emission computed tomographysomatostatin analogspongioblastoma multiformetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttheranosticstherapeutic efficacytherapeutic responsetherapeutic targettherapy efficacytherapy responsetreatment responsetreatment responsivenesstumortumor cell metastasistumor growthtumor microenvironmentuptakexeno-transplantxeno-transplantation
Description preview
ABSTRACT
Radiopharmaceutical therapy (RPT) has received approval for the treatment of thyroid (131I), neuroendocrine
(177Lu-Dotatate), neuroblastoma (131I-MIBG), lymphomas (90Y-antiCD20, 131I-anti-CD20), and prostate cancers
(223Ra, 177Lu-PSMA). The efficacy of targeted RPT for these cancers has motivated RPT approaches that
broaden its use in…
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