grant
Systematic Analysis of the Actin Cytoskeleton and Directed Cell Migration
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Feb 2019Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026ActinsArchitectureAreaAssayBioassayBiochemicalBiological AssayBiological FunctionBiological ProcessCardiovascular DiseasesCause of DeathCell AdhesionCell BodyCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell ShapeCellsCellular AdhesionCellular FunctionCellular MatrixCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular biologyCharacteristicsClathrinCuesCytoskeletal SystemCytoskeletonDataDiseaseDisorderDisseminated Malignant NeoplasmEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEndocytosisEngineering / ArchitectureEnvironmentEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorEquilibriumFibrosisGenesGrantImage AnalysesImage AnalysisImmune responseIntegrinsIntegrins Extracellular MatrixKO miceKnock-out MiceKnockout MiceLightMediatingMetastasisMetastasizeMetastatic CancerMetastatic LesionMetastatic Malignant NeoplasmMetastatic MassMetastatic NeoplasmMetastatic TumorMicroscopeMicroscopyMolecularMorphogenesisMotilityNeoplasm MetastasisNull MouseOrganism-Level ProcessOrganismal ProcessPathologic ProcessesPathological ProcessesPathway interactionsPhotoradiationPhysiologic ProcessesPhysiological ProcessesPlayProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProteomicsPublishingRegulationRoleSecondary NeoplasmSecondary TumorSignal PathwaySubcellular ProcessTestingTractionTyrosine KinaseTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein KinaseWorkWound Repairactive controlbalancebalance functioncancer metastasiscardiovascular disordercell biologycell motilityconditional knock-outconditional knockouthost responsehydroxyaryl protein kinaseimage evaluationimage interpretationimmune system responseimmunoresponseinterdisciplinary approachintracellular skeletonmigrationmorphogenetic processmouse modelmultidisciplinary approachmurine modeloptogeneticspathwayresponsesocial roletumortumor cell metastasistyrosyl protein kinasewound healingwound recoverywound resolution
Description preview
PROJECT ABSTRACT
Cell motility is one of the oldest problems in cell biology as the movement of cells was one of the first things
noted when the microscope was developed in the 17th century. The last sixty years of work revealed that the
molecular underpinnings of motility involve the active control of the cytoskeleton. However, many questions…
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