grant
Syphilis in pregnancy: placental histopathology and transcriptomic linkage to outcomes
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 17 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY202521+ years oldAcuteAddressAdultAdult HumanAmnionitidesAntibodiesAntigen-Antibody ComplexBacterial InfectionsBiologicalBlood VesselsBody TissuesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCMVCase SeriesCell BodyCell Surface AntigensCellsCells Placenta-TissueChorioamnionitisChorionic villiChronicChronologic Fetal MaturityClinicalClinical DataClinical EvaluationClinical ManagementClinical TestingClinical and Translational Science AwardsCommunicable DiseasesComputational BiologyComputer ModelsComputerized ModelsCongenital SyphilisConsensus WorkshopCoupledCytomegalovirusDataDecidua BasalisDiscipline of obstetricsDiseaseDisorderDysfunctionEnvironmentExpression SignatureFetal AgeFetal Growth RestrictionFetal Growth RetardationFoundationsFrequenciesFunctional disorderFutureGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionGenomicsGestationGestational AgeGynecologyHCMVHigh PrevalenceHistopathologyHyperplasiaHyperplasticIUGRImmuneImmune ComplexImmune EvasionImmune responseImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunological Surface MarkersImmunologyInfectionInfection of amniotic cavityInfection of amniotic sac and membranesInfectious DiseasesInfectious DisorderInflammatoryIntrauterine Growth RetardationInvestigatorsK23 AwardK23 MechanismK23 ProgramKnowledgeLesionLinkMacrophageMaternal placentaMedical DirectorsMedical centerMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMentorshipMolecularMorbidityMorbidity - disease rateMφNeonatal MortalityNetwork AnalysisNormal PlacentomaObstetricsOntologyOrder SpirochaetalesOutcomePathologyPathway AnalysisPathway interactionsPatientsPerinatalPeripartumPhenotypePhysician ExecutivesPhysiopathologyPlacentaPlacenta BiologyPlacenta Embryonic TissuePlacental BiologyPlacental VilliPlacentomePopulationPregnancyPregnancy OutcomePremature BirthPremature LaborPremature Obstetric LaborPrematurely deliveringPreterm BirthPreterm LaborRNA ExpressionReproductive BiologyResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskS agalactiaeS. agalactiaeSalivary Gland VirusesScienceSpirochaetalesSpirochetesStreptococcus Group BStreptococcus agalactiaeSurface AntigensSyphilisT pallidumT-Cell ActivationT-CellsT-LymphocyteT. pallidumT8 CellsT8 LymphocytesTestingTissuesTrainingTranscriptionTreponema pallidumTreponema pallidum subsp. pallidumTreponema pallidum subspecies pallidumUnited StatesVillousVillusViral DiseasesVirus Diseasesactivate T cellsadulthoodadverse pregnancy outcomeapplied learningbacteria infectionbacterial diseasebiologicbiomarker developmentbiomarker identificationcareercareer developmentcell typeclinical phenotypeclinical testcomputational modelingcomputational modelscomputer based modelscomputer biologycomputerized modelingcongenital infectioncytomegalovirus groupdeath among neonatesdeath among newbornsdeath in neonatesdeath in newborndigitalexperienceextracellularfetalgene expression patterngene expression signatureglobal gene expressionglobal transcription profilegreat poxhands-on learninghealthy pregnancyhigh riskhost responseidentification of biomarkersidentification of new biomarkersimmune evasiveimmune microenvironmentimmune system responseimmunogenicimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimpaired fetal growthinsightinteractive engagementinteractive learningintra-amniotic infectionintra-uterine growth restrictionintra-uterine growth retardationintraamniotic infectionintrauterine growth restrictionmarker identificationmaternal sepsismortalitymortality among neonatesmortality among newbornsmortality in neonatesmortality in newbornsneonatal deathneonatal demiseneonatal outcomeneonatal sepsisnewborn deathnewborn mortalitynovelpathogenpathophysiologypathwaypremature childbirthpremature deliverypremature neonatespremature newbornprenatal growth disorderpreterm deliverypreterm neonatepreterm newbornpreventpreventingprogramsprotein expressionresearch clinical testingresponsesepsis in mothersstillbirthstillbornsystemic inflammationsystemic inflammatory responsetherapeutic agent developmenttherapeutic developmenttherapeutic targetthymus derived lymphocytetooltranscriptional profiletranscriptional signaturetranscriptometranscriptomicstumor immune microenvironmenttumor-immune system interactionsvascularviral infectionviral transmissionvirus infectionvirus transmissionvirus-induced disease
Description preview
PROJECT SUMMARY
Syphilis, caused by the spirochete Treponema pallidum subsp. pallidum (T. pallidum), is an important cause of
stillbirth, preterm delivery, and neonatal death. In untreated syphilis in pregnancy, histopathologic findings of
necrotizing funisitis, proliferative vascular changes in the villi, acute or chronic villitis with a…
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