grant
Synthetic fentanyls adversely affect the blood-brain barrier and HIV replication in the context of neuroHIV
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 15 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAIDSAIDS VirusAccelerationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusActiqAddressAdhesion MoleculeAdventitial CellAffectAssayAstrocytesAstrocytusAstrogliaAutoregulationBBB functionBBB permeabilizationBBB permeableBindingBioassayBiological AssayBlood - brain barrier anatomyBlood VesselsBlood leukocyteBlood monocyteBlood-Brain BarrierBrainBrain Nervous SystemCaringCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell Communication and SignalingCell SignalingCellsCellular MatrixChemicalsClassificationComplexCytoskeletal SystemCytoskeletonDataDevelopmentDisease OutbreaksDrug ScreeningDrugsDuragesicDysfunctionEncephalonEndotheliumEnvironmentEpidemicEventFentanestFentanylFentylFloodingFloodsFunctional disorderGatekeepingGene ExpressionGeneticHIVHIV InfectionsHIV associated neurological diseaseHIV associated neurological disorderHIV-1HIV-IHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHemato-Encephalic BarrierHomeostasisHortega cellHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1Illicit DrugsImmuneImmune SurveillanceImmune infiltratesImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic SurveillanceImmunologicalImmunologicallyImmunologicsImmunosurveillanceImpairmentInfectionInflammatoryInflammatory ResponseInjecting drug userInjection Drug UserInjectionsInnate ImmunityIntracellular Communication and SignalingInvestigationKineticsLAV-HTLV-IIILeukocytesLeukocytes Reticuloendothelial SystemLife CycleLife Cycle StagesLinkLymphadenopathy-Associated VirusMacrophageMarrow leukocyteMarrow monocyteMedicationMicrofluidicsMicrogliaModelingModern ManMolecularMolecular InteractionMφNative ImmunityNatural ImmunityNerve CellsNerve UnitNetwork AnalysisNeural CellNeurocyteNeurologic ManifestationsNeurologic Signs and SymptomsNeurologic SymptomsNeurological ManifestationsNeurological Signs and SymptomsNeuronsNon-Specific ImmunityNonspecific ImmunityOccluding JunctionsOpiate ReceptorsOpiate userOpiatesOpioidOpioid ReceptorOpioid drug userOutbreaksPWIDPWUOPathogenesisPathologicPathway AnalysisPathway interactionsPericapillary CellPericytesPerivascular CellPersonsPharmaceutical PreparationsPhentanylPhysiological HomeostasisPhysiopathologyPlayPoliciesPublishingPumpReceptor ActivationReceptor ProteinReportingResearch SupportRiskRoleRouget CellsSeminalSignal TransductionSignal Transduction SystemsSignalingStructureSystematicsTestingTight JunctionsTissue EngineeringToxicologyUpregulationUrineViralViral reservoirVirusVirus reservoirVirus-HIVWhite Blood CellsWhite CellZonula Occludensabused drugabused drugsantiretroviral therapyantiretroviral treatmentastrocytic gliabiocompatibilitybioengineered tissuebiological signal transductionbiomaterial compatibilityblood-brain barrier functionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier functionbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain cellbrain endothelial cellbrain microvascular endothelial cellbrain vascular endothelial cellcell adhesion proteincerebral endothelial cellcerebral microvascular endothelial cellcerebral vascular endothelial cellcohortdevelopmentaldrug abuseddrug actiondrug marketdrug of abusedrug/agentdrugs abuseddrugs of abuseemergent outbreakemerging outbreakengineered tissueexperimentexperimental researchexperimental studyexperimentsfentalogsfentaloguesfentanyl analogfentanyl exposurefentanyl usegatekeepergitter cellhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsillicit drug useimmune cell infiltrateinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinfection rateinnovateinnovationinnovativeinsightintracellular skeletonlife coursemanufacturemesogliamicroglial cellmicrogliocytemigrationmonocyteneural inflammationneural manifestationneuro-AIDSneuro-HIVneuroAIDSneuroHIVneuroinflammationneuroinflammatoryneuronalneuropathologicneuropathologicalneuropathologynew outbreaknon-medical opioid usenonmedical opioid usenovelnovel outbreakopiate crisisopiate misuseopioid crisisopioid epidemicopioid misuseopioid useroverdose deathoverdose fatalitiespathophysiologypathwaypeople who inject drugspeople who inject illicit drugspeople who use opioidsperivascular glial cellpersons who inject drugspersons who use opioidspharmacologicrate of infectionreceptorresponsescreeningscreeningssocial rolesynthetic opiatesynthetic opioidthree dimensionaltooltranslational modelvascularwhite blood cellwhite blood corpuscleµfluidic
Description preview
In the past two to three decades, there has been a surge in the use, abuse, and misuse of opioids. Among
opioid users, Illicit fentanyl use has become widespread in the US. Moreover, synthetic fentanyls rapidly flood
the illicit drug market due to their cheap manufacturing, enhanced potency, and chemical composition that
evades toxicology…
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