grant
Synthesis and Biochemical Evaluation of Ruthenium Compounds
Organization BARD COLLEGELocation ANNANDALE-ON-HUDSON, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Amino AcidsAnti-Bacterial AgentsAnti-Cancer AgentsAnti-diabetic AgentsAnti-diabetic DrugsAntifolatesAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsArchitectureAttentionBacteriaBacterial InfectionsBindingBinding SitesBiochemicalBiologic ModelsBiologicalBiological ModelsBiotechBiotechnologyCDDPCancer DrugCancersCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumCombining SiteComplexCysplatynaD-MannoseDNADeoxyribonucleic AcidDiabetes MellitusDichlorodiammineplatinumDihydrofolate DehydrogenaseDihydrofolate ReductaseDimethylbiguanidineDimethylguanylguanidineDiseaseDisorderDrug resistanceDrugsEngineering / ArchitectureEnzyme GeneEnzymesEukaryotaEukaryoteEvaluationFolateFolate AnalogFolate InhibitorsFolic AcidFolic Acid AnalogFolic Acid AntagonistsFolic Acid InhibitorsFolic Acid ReductaseFungus DiseasesGoalsH-bondHydrogen BondingLaboratoriesLigandsLytotoxicityM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMalignant CellMalignant NeoplasmsMalignant TumorMannopyranoseMannopyranosideMannoseMarketingMeasuresMedicationMedicineMetallo-Organic CompoundsMetforminMethotrexateMethotrexate MethylaminopterinMethotrexatumMetotrexatoModel SystemMolecular InteractionMolecular TargetMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMycosesN,N-dimethyl-imidodicarbonimidic diamideNeoplastic Disease Chemotherapeutic AgentsNon-Polyadenylated RNANucleotide BiosynthesisNucleotide SynthesisNucleotidesOrganometallic CompoundsPathway interactionsPeyrone's ChloridePeyrone's SaltPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenforminPhenylethylbiguanidePlatinumPlatinum BlackPlatinum DiamminodichlorideProkaryotaeProkaryotic CellsProteinsPt elementPteroylglutamic AcidPublic HealthPurines/Pyrimidines/Nucleotides/Nucleic Acids MetabolismRNARNA BindingRNA Gene ProductsRNA boundReactive SiteReportingResearchRibonucleic AcidRoleRu elementRutheniumRuthenium CompoundsSolubilitySpecificityStructureSubcellular ProcessTB infectionTestingTetrahydrofolate DehydrogenaseTherapeuticTherapeutic AgentsThiophenesToxic effectToxicitiesTransition ElementsTuberculosisTumor-Specific Treatment AgentsVitamin Maminoacidanaloganti-bacterialanti-cancer druganti-diabeticanti-microbialantimicrobialaqueousbacteria infectionbacterial diseasebiologiccancer cellcis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumcytotoxicitydesigndesigningdiabetesdisseminated TBdisseminated tuberculosisdrug resistantdrug/agentenzyme activityfolate antagonistfunctional groupfungal infectionfungus infectionimprovedinfection due to Mycobacterium tuberculosismalignancymetal complexneoplasm/cancernew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapynucleotide metabolismpathwaypharmaceuticalprokaryoteresistance to Drugresistant to Drugsmall moleculesocial rolethiofuranthioletransition metaltuberculosis infectiontuberculous spondyloarthropathyundergradundergraduateundergraduate studentvitamin Bcwater solubility
Description preview
Project Summary
Transition metal compounds have been used as therapeutic agents. However, treatment
with these compounds, for example cisplatin, can lead to drug resistance and poor efficacy.
Ruthenium has been studied as an alternative to other transition metals. The aims of this
project are to carry out the synthesis, characterization, and…
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