grant
Synergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunction
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 17 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-KinaseAcidsAcuteAffectAllograftingAlveolarAlveolar MacrophagesAntigen-Antibody ComplexAntigenic DeterminantsAntigensAssayAttenuatedAutoantibodiesAutoantigensAutologous AntigensBeta Proprotein Interleukin 1BindingBinding DeterminantsBioassayBiological AssayBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteCCL2CCL2 geneCXCL2CXCL2 geneCaringCell BodyCell Communication and SignalingCell SignalingCellsChemokine, CC Motif, Ligand 2Chemokine, CXC Motif, Ligand 2ChronicChronic lung diseaseClinicalClinical ResearchClinical StudyClosure by LigationCollaborationsCollagen Type VComplementComplement ActivationComplement ProteinsDataDevelopmentDysfunctionEndotheliumEpitheliumEpitope spreadingEpitopesEsophagusExtracellular Matrix ProteinsExtravasationFc ReceptorFunctional disorderGRO Protein, BetaGRO2GRO2 OncogeneGRObGROβGrafting ProcedureHourIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImmuneImmune ComplexImmunesIndustry CollaborationIndustry CollaboratorsInjuryInterleukin 1betaInterleukin-1 betaInterleukin-1βInterventionIntracellular Communication and SignalingInvestigatorsLeakageLifeLigationLinkLungLung GraftingLung Respiratory SystemLung TransplantationLung damageMCAFMCP-1MCP1MIP-2AMIP2-alphaMIP2AMIP2αMMP-8MMPsMarrow NeutrophilMarrow monocyteMatrix Metalloproteinase-8Matrix MetalloproteinasesMediatingMethodsMiceMice MammalsModelingMolecularMolecular InteractionMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMurineMusNeutrophil CollagenaseNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteOrganOrgan TransplantationOrgan TransplantsOutcomePI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePMNL CollagenasePathogenesisPathologicPathway interactionsPatient CarePatient Care DeliveryPatientsPatternPermeabilityPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhysiopathologyPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPostoperativePostoperative PeriodPreinterleukin 1 BetaProductionPtdIns 3-KinasePublishingPulmonary GraftPulmonary MacrophagesPulmonary TransplantPulmonary TransplantationResearch PersonnelResearchersResolutionRiskRoleSCYA2SCYB2Self-AntigensSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine A2Small Inducible Cytokine Subfamily B, Member 2SolidSpillageTIL4TLR2TLR2 geneTLR2 receptorTestingToll-Like Receptor 2Toll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4TranslatingTransplant RecipientsTransplantationTubulinType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseWorkallograft rejectionantibody receptorantigen bindingantigen boundantigen spreadingaspirateattenuateattenuatesautoimmune antibodyautoreactive antibodybiological signal transductioncare for patientscare of patientscaring for patientschronic pulmonary diseaseclinical applicabilityclinical applicationcomplement pathway regulationcomplementationdevelopmentalend stage diseasegraft dysfunctionimmunogenimmunogenicimprovedinjuriesinsightlung allograftlung injurylung transplantmacrophage inflammatory protein 2migrationmitochondrial dysfunctionmonocytemortalitymouse modelmurine modelneutrophilorgan allograftorgan graftorgan xenograftpathophysiologypathwaypreventpreventingprospectivepulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrecruitrepairrepairedresolutionsself reactive antibodysocial roletransplanttransplant patientβ-GRO protein
Description preview
PROJECT 1 SUMMARY
Primary graft dysfunction (PGD) affects over 50% of recipients within the first 24-72 hours after lung
transplantation. PGD is the dominant risk for post-operative mortality, transplant-associated multi-organ
dysfunction, and chronic lung allograft rejection. We found that 30% of patients with chronic end-stage disease
develop…
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