grant
Synergistic Effects of Unacylated Ghrelin and Endurance Exercise on Sarcopenia and Mobility Loss
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026Active OxygenAgeAgingAntioxidantsAttenuatedBioenergeticsBiogenesisBody TissuesCell CountCell Growth in NumberCell MultiplicationCell NumberCell ProliferationCellular ProliferationChronic DiseaseChronic IllnessCombined Modality TherapyCommunicationDNA ReplicationDNA SynthesisDNA biosynthesisDataDecline in mobilityDecrease in mobilityDecreased mobilityDenervationDeuteriumDeuterium OxideDimethylbiguanidineDimethylguanylguanidineDiminished mobilityDiseaseDisorderDrugsDysfunctionEmbryonic Muscle CellsEventExerciseFemaleFoundationsFree RadicalsFunctional disorderFutureGastrocnemius MuscleGeneralized GrowthGenerationsGenesGoalsGrowthH2 isotopeHealthHeavy WaterHumanInflammationInnovative TherapyInterventionInvestigationLiteratureMeasuresMediatingMediatorMedical Care CostsMedicationMedulla SpinalisMetabolicMetabolic Protein DegradationMetforminMiceMice MammalsMitochondriaMobility declineMobility impairmentModern ManMotorMotor CellMotor NeuronsMultimodal TherapyMultimodal TreatmentMurineMusMuscleMuscle AtrophyMuscle CellsMuscle TissueMuscle functionMuscular AtrophyMyoblastsMyocytesMyoneural JunctionN,N-dimethyl-imidodicarbonimidic diamideNerve CellsNerve UnitNeural CellNeurocyteNeuromuscular JunctionNeuronsOrigin of LifeOxidative PhosphorylationOxidative Phosphorylation PathwayOxidative StressOxygen ConsumptionOxygen RadicalsPathway interactionsPersonal SatisfactionPharmaceutical PreparationsPhosphorylationPhysiopathologyPlayPrecursor Muscle CellsPredispositionPro-OxidantsProtein BiosynthesisProtein PhosphorylationProtein TurnoverProteinsReactive Oxygen SpeciesReduced mobilityReduction in mobilityRegulatory Protein DegradationRespirationResveratrolRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRodent ModelRoleSafetySignaling MoleculeSkeletal MuscleSourceSpinal CordSusceptibilityTestingTissue GrowthTissuesTrainingVoluntary MuscleWater-d2adult youthage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentaged groupaged groupsaged individualaged individualsaged miceaged mouseaged peopleaged personaged personsaged populationaged populationsagesaging populationapoptosis of neuronal cellsattenuateattenuateschronic disordercombination therapycombined modality treatmentcombined treatmentdifferential expressiondifferentially expresseddisabilitydrug/agenteffective interventionelderly miceendurance exerciseexercise interventionexercise traininggastrocnemiusghrelinimprovedin vivoinflammation markerinflammatory markerinhibitorinnervationinsulin sensitivitylean body massmalemedical costsmedical expensesmimeticsmitochondrialmotoneuronmulti-modal therapymulti-modal treatmentmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle wastingmuscularnerve cell deathnerve cell lossnerve supplyneuron apoptosisneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal apoptosisneuronal cell deathneuronal cell lossneuronal cells programmed cell deathneuronal deathneuronal lossneurons programmed cell deathold miceolder adultolder adulthoodontogenypathophysiologypathwayphysical activity interventionpopulation agingpreservationpreventpreventingprogrammed cell death of neuronal cells by apoptosisprogrammed cell death of neurons by apoptosisprotein degradationprotein homeostasisprotein synthesisproteostasisrapid growthrespiratory mechanismresponsesarcopeniasarcopenicsocial rolesuccesstranscriptional differencestranscriptomicstranslational opportunitiestranslational potentialtreatment effectwell-beingwellbeingyoung adultyoung adult ageyoung adulthood♀♂
Description preview
Project Summary/Abstract
Sarcopenia, the progressive loss of muscle mass and function, universally impacts the aging population,
contributing to loss of mobility and independence in older adults. With the rapid growth of the aging population,
there is an urgent need for effective strategies against sarcopenia. Exercise is the most effective…
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